CEST AND MAGNETIC TRANSFER MRI OF LIVER FIBROSIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 虽然肝病目前在美国被列为成人死亡的第七大原因， 美国，诊断和监测肝病患者进展的金标准， 病理学仍然局限于肝活检。肝活检可能与取样变异性有关， 重现性差和严重并发症，因此必须开发非侵入性技术 能够诊断不同的肝脏疾病。随着高性能磁共振技术的出现 (MR)系统和先进的序列，MRI显示出改善和非侵入性的潜力， 评估肝脏疾病。快速自旋回波或单次激发技术，通常与脂肪相结合 抑制，是肝脏MRI程序中最常用的T2加权序列。肝脏MRI 高度依赖于造影剂的施用，尤其是当检测和 局部病变的表征是问题。目前，没有一种MRI技术 对于检测不同的肝脏病理是最佳的。本项目的目标是开发CEST 和MT MRI技术监测人类和动物慢性肝病的进展 模型

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While liver disease is currently ranked as the seventh leading cause of adult death in the United States, the gold standard to diagnose and monitor the progress of patients afflicted with hepatic pathologies remains limited to liver biopsy. Liver biopsies can be associated with sampling variability, poor reproducibility and major complications, rendering it essential to develop non-invasive techniques able to diagnose different liver conditions. With the advent of high performance magnetic resonance (MR) systems and advanced sequences, MRI shows potential for improved and non-invasive assessment of liver disease. Fast spin echo or single shot techniques, often combined with fat suppression, are the most common T2 weighted sequences used in liver MRI procedures. Liver MRI is highly dependent on the administration of contrast agents, especially when detection and characterization of focal lesions are the issues. Currently, there is no single MRI technique that is optimal for detecting the different liver pathologies. The objective of this project is to develop CEST and MT MRI techniques for monitoring the progression of chronic liver diseases in human and animal models.