X-RAY CRYSTALLOGRAPHIC STUDIES OF HUMAN TOPOISOMERASE

人类拓扑异构酶的 X 射线晶体学研究

• 批准号: 8170172
• 负责人: HIDONG KIM
• 金额: $ 0.41万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170172
• 关键词: Antineoplastic Agents; Complex; Computer Retrieval of Information on Scientific Projects Database; DNA biosynthesis; Development; Enzymes; Funding; Grant; Human; Institution; Pharmaceutical Preparations; Research; Research Personnel; Resources; Roentgen Rays; Source; Structure; Synchrotrons; Topoisomerase; Type I DNA Topoisomerases; United States National Institutes of Health; design; human DNA; human TOP1 protein; small molecule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Synchrotron beamtime is requested for X-ray crystallographic studies of human DNA topoisomerase I (topo I). Topo I is an essential enzyme in DNA replication, and the target of anti-cancer drugs. The synchrotron beamtime will be used to determine structures of complexes of topo I with small molecule compounds for design and development of new topo I drugs.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人DNA拓扑异构酶I(TOPO I)的X射线结晶学研究需要同步加速器光束时间。Topo I是DNA复制过程中的一个重要酶，也是抗癌药物的靶点。同步加速器波束时间将用于确定TOPO I与小分子化合物的络合物的结构，用于设计和开发新的TOPO I药物。