X-RAY CRYSTALLOGRAPHIC STUDIES OF HUMAN TOPOISOMERASE

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 人类 DNA 拓扑异构酶 I (topo I) 的 X 射线晶体学研究需要同步加速器光束时间。 Topo I 是 DNA 复制中必需的酶，也是抗癌药物的靶点。 同步加速器射束时间将用于确定拓扑 I 与小分子化合物的复合物结构，以设计和开发新的拓扑 I 药物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Synchrotron beamtime is requested for X-ray crystallographic studies of human DNA topoisomerase I (topo I). Topo I is an essential enzyme in DNA replication, and the target of anti-cancer drugs. The synchrotron beamtime will be used to determine structures of complexes of topo I with small molecule compounds for design and development of new topo I drugs.