NORTHEAST STRUCTURAL GENOMICS CONSORTIUM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 东北结构基因组学联盟（Northeast Structural Genomics Consortium，NESGC）是全球四大蛋白质结构研究中心之一。蛋白质结构倡议（PSI-2）的第二阶段必须产生大量独特的蛋白质结构，以满足PSI-2测序基因的结构覆盖目标。NESGC还必须开发技术和方法，使蛋白质的生产和结构测定更便宜，更有效，更有可能成功。这些结构将帮助研究人员发现蛋白质的功能，设计更好的实验，并研究关键的生物医学问题，如蛋白质折叠，结构预测以及蛋白质家族和折叠的组织。此外，这些研究的结果将有助于更快地鉴定有前途的新结构药物，更好地治疗遗传和感染性疾病

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Northeast Structural Genomics Consortium (NESGC) is one of the four large centers for the determination of unique protein structures. The integrated second phase of the Protein Structure Initiative (PSI-2) must produce a large number of unique protein structures to meet the PSI-2 goals for structural coverage of sequenced genes. NESGC must also develop technologies and methodologies that will make the production and structural determination of proteins less expensive, more efficient, and more likely to be successful. These structures will help researchers discover the functions of proteins, design better experiments, and study key biomedical problems such as protein folding, structure prediction, and the organization of protein families and fold. In addition, the results of these studies will be useful for faster identification of promising new structure-based medicines, better therapeutics for treating both genetic and infectious diseases