NORTHEAST STRUCTURAL BIOLOGY CONSORTIUM STRUCTURAL BIOLOGY GENOMICS RESEARCH

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 国家普通医学科学研究所（NIGMS）支持大规模的东北结构基因组学联盟（NESGC）确定独特的蛋白质结构，并支持纽约膜蛋白结构联盟（NYCOMPS）确定膜蛋白的结构。在蛋白质结构倡议（PSI-2）的第二阶段，预计NESG将产生至少700个独特的蛋白质结构，以满足PSI-2的目标。这些结构将帮助研究人员发现蛋白质的功能，设计更好的实验，并研究关键的生物医学问题，如蛋白质折叠，结构预测以及蛋白质家族和折叠的组织。此外，这些研究的结果将有助于更快地鉴定有前途的新结构药物，更好地治疗遗传和感染性疾病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The National Institute of General Medical Sciences (NIGMS) supports the large-scale Northeast Structural Genomics Consortium (NESGC) for the determination of unique protein structures and also supports the New York Consortium on Membrane Protein Structure (NYCOMPS) for structure determination of membrane proteins. In the integrated second phase of the Protein Structure Initiative (PSI-2) NESG is expected to produce at least 700 unique protein structures to meet the PSI-2 goals. These structures will help researchers discover the functions of proteins, design better experiments, and study key biomedical problems such as protein folding, structure prediction, and the organization of protein families and folds. In addition, the results of these studies will be useful for faster identification of promising new structure-based medicines, better therapeutics for treating both genetic and infectious diseases.