PROTEINS INVOLVED IN CYTOKINESIS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 胞质分裂是完成细胞分裂的过程， 两个子细胞。 在动物细胞中，胞质分裂是通过收缩 皮质收缩环 收缩环由蛋白质聚合物网络组成 包括肌动蛋白丝、运动肌球蛋白II的双极丝和隔蛋白丝。 收缩环还含有交联剂苯胺醛，它直接与所有三个细丝结合 类型，以及调节肌动蛋白成核、加帽、聚合、分解 和交联。 虽然我们已经知道许多收缩环的组成部分， 关于这种结构的分子结构还有待了解。 我们正在努力 构建一个分子网络，通过寻找相互作用子， 在已知的环成分中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cytokinesis is the process that completes cell division, physically partitioning the mother cell into the two daughter cells. In animal cells, cytokinesis is accomplished by constriction of a cortical contractile ring. Contractile rings are composed of a network of protein polymers that includes actin filaments, bipolar filaments of the motor myosin II, and septin filaments. Contractile rings also contain the crosslinker anillin, which binds directly to all three filament types, and proteins that regulate actin nucleation, capping, polymerization, disassembly, and crosslinking. Although we already know many of the contractile ring components, much is still to be learned about the molecular architecture of this structure. We are trying to build a molecular network that allows constriction to happen by looking for interactons among known ring components by mass-spectrometry.