PROTEINS INVOLVED IN CYTOKINESIS

参与细胞分裂的蛋白质

• 批准号: 8171424
• 负责人: Karen F Oegema
• 金额: $ 0.71万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171424
• 关键词: Actins; Animals; Architecture; Binding; Cell division; Cells; Computer Retrieval of Information on Scientific Projects Database; Crosslinker; Cytokinesis; Filament; Funding; Grant; Institution; Learning; Mass Spectrum Analysis; Microfilaments; Molecular; Mothers; Motor; Myosin Type II; Polymers; Process; Proteins; Research; Research Personnel; Resources; Source; Structure; United States National Institutes of Health; anillin; constriction; crosslink; daughter cell; polymerization

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cytokinesis is the process that completes cell division, physically partitioning the mother cell into the two daughter cells. In animal cells, cytokinesis is accomplished by constriction of a cortical contractile ring. Contractile rings are composed of a network of protein polymers that includes actin filaments, bipolar filaments of the motor myosin II, and septin filaments. Contractile rings also contain the crosslinker anillin, which binds directly to all three filament types, and proteins that regulate actin nucleation, capping, polymerization, disassembly, and crosslinking. Although we already know many of the contractile ring components, much is still to be learned about the molecular architecture of this structure. We are trying to build a molecular network that allows constriction to happen by looking for interactons among known ring components by mass-spectrometry.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 胞质分裂是完成细胞分裂的过程，物理上分裂母细胞 进入两个子细胞。在动物细胞中，胞质分裂是通过收缩一个 皮质收缩环。收缩环由蛋白质聚合物网络组成。 这包括肌动蛋白细丝、运动肌球蛋白II的双极细丝和隔素细丝。 收缩环还含有交联剂苯丙素，它直接与所有三种细丝结合。 类型，以及调节肌动蛋白成核、封顶、聚合、分解的蛋白质， 和交联剂。虽然我们已经知道了许多收缩环的成分，但很多 关于这种结构的分子结构仍有待了解。我们正在努力 建立一个分子网络，通过寻找相互作用子来允许收缩发生 在已知的环成分中通过质谱分析。