IDENTIFICATION OF C05C89 INTERACTING PROTEINS

C05C89 相互作用蛋白的鉴定

• 批准号: 8171386
• 负责人: Karen F Oegema
• 金额: $ 0.24万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171386
• 关键词: Cell physiology; Centrioles; Centrosome; Cilia; Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; Institution; Microtubule Stabilization; Organelles; Preparation; Proteins; Research; Research Personnel; Resources; Source; United States National Institutes of Health; interest; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Centrioles are small cylindrical organelles that are important in the stabilization of microtubules which perform several important cellular functions including centrosome assembly and cilia formation. Understanding how centrioles perform these different functions is of great interest. The goal of this project is to identify C05C8.9 interacting proteins. C05C8.9 is a novel centriolar protein that was identified in a TAP preparation of SAS-4 which is required for cilia formation.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 中心粒是一种小的圆柱形细胞器，在微管的稳定中起着重要的作用，它执行着几个重要的细胞功能，包括中心体组装和纤毛形成。了解中心粒如何执行这些不同的功能是非常有意义的。该项目的目标是鉴定C05C8.9相互作用蛋白。C05C8.9是一种新的中心粒蛋白，是在纤毛形成所需的SAS-4的TAP制剂中鉴定出来的。