INTEGRIN ASSOCIATED PROTEINS
INTEGRIN ASSOCIATED PROTEINS
批准号:
8171294
负责人:
Kenneth Yamada
金额:
$0.24万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-09-01 至 2011-08-31
关键词:
ActinsAdhesionsCD47 AntigenCell ProliferationCell physiologyCell-Matrix JunctionComplexComputer Retrieval of Information on Scientific Projects DatabaseCytoskeletonExtracellular MatrixFundingFutureGrantInstitutionIntegrinsLigandsMalignant Epithelial CellMalignant NeoplasmsMolecularMouth CarcinomaNeoplasm MetastasisPathway interactionsPhenotypeProteomicsRegulationResearchResearch PersonnelResourcesSignal PathwaySourceUnited States National Institutes of Healthcell motilityextracellularmalignant mouth neoplasmmigrationreceptorreceptor binding
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Integrin receptors bind to extracellular matrix (ECM) ligands and selectively connect to intracellular signaling pathways and the actin cytoskeleton to regulate adhesion-dependent cellular processes. In cancer, the dynamic regulation of adhesion by integrins is critical for cell attachment to ECM, cell proliferation, invasion and cell migration. However, the intracellular downstream effectors of integrins that are important for oral cancer migration, invasion and metastasis are not well understood. Our aim is to compare the composition of integrin associated complexes derived from highly and poorly metastatic oral carcinoma cells. This proteomics study will identify candidate integrin downstream factors that either associate with distinct integrin receptors or specifically associate with integrins in a particular metastatic state. Future studies will delineate whether the identified factors regulate invasion and metastasis, as well as the molecular pathways involved in regulating these metastatic phenotypes.
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INTEGRIN ASSOCIATED PROTEINS
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批准号:8365830
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项目类别:
-
资助金额:$1.28万
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财政年份:2011
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负责人:Kenneth Yamada
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依托单位:
INTEGRIN ASSOCIATED PROTEINS
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批准号:7957753
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项目类别:
-
资助金额:$0.33万
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财政年份:2009
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负责人:Kenneth Yamada
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依托单位:
Cell-Surface Interactions in Pathogenesis
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批准号:10246740
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项目类别:
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资助金额:$106.48万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Matrix Organization and Dimensionality
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批准号:10703883
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项目类别:
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资助金额:$27.65万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Matrix Organization and Dimensionality
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批准号:7733931
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项目类别:
-
资助金额:$72.3万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Craniofacial Developmental Dynamics
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批准号:10917907
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项目类别:
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资助金额:$67.49万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Craniofacial Developmental Dynamics
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批准号:8148623
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项目类别:
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资助金额:$71.42万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Cell-Matrix Interactions and Migration
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批准号:8148622
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项目类别:
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资助金额:$66.66万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Craniofacial Developmental Dynamics
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批准号:9339225
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项目类别:
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资助金额:$89.45万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Cell-Matrix Interactions and Migration
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批准号:7967049
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项目类别:
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资助金额:$69.33万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Cell-Matrix Interactions and Migration
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批准号:8553326
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项目类别:
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资助金额:$57.48万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Matrix Organization and Dimensionality
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批准号:8553345
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项目类别:
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资助金额:$57.48万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Cell-Matrix Interactions and Migration
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批准号:8743734
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项目类别:
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资助金额:$51.1万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Matrix Organization and Dimensionality
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批准号:8743752
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项目类别:
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资助金额:$63.88万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Craniofacial Developmental Dynamics
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批准号:9555610
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项目类别:
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资助金额:$154.34万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Matrix Organization and Dimensionality
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批准号:9339231
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项目类别:
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资助金额:$51.12万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Matrix Organization and Dimensionality
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批准号:7593389
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项目类别:
-
资助金额:$58.42万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Cell-Surface Interactions in Pathogenesis
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批准号:9555620
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项目类别:
-
资助金额:$88.19万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Cell-Matrix Interactions and Migration
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批准号:10917906
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项目类别:
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资助金额:$40.49万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
Cell-Matrix Interactions and Migration
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批准号:8344117
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项目类别:
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资助金额:$56.8万
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财政年份:--
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负责人:Kenneth Yamada
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依托单位:
海外基金