INTEGRIN ASSOCIATED PROTEINS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 整合素受体与细胞外基质(ECM)配体结合，选择性地连接到细胞内信号通路和肌动蛋白细胞骨架，调节黏附依赖的细胞过程。在癌症中，整合素对黏附的动态调节对于细胞与细胞外基质的黏附、细胞的增殖、侵袭和细胞的迁移至关重要。然而，整合素的细胞内下游效应对口腔癌的迁移、侵袭和转移具有重要作用，目前还不清楚。我们的目的是比较来自高转移和低转移口腔癌细胞的整合素相关复合体的组成。这项蛋白质组学研究将确定候选的整合素下游因子，这些因子要么与不同的整合素受体相关，要么与特定转移状态的整合素特异相关。未来的研究将描述已识别的因素是否调节侵袭和转移，以及参与调节这些转移表型的分子途径。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Integrin receptors bind to extracellular matrix (ECM) ligands and selectively connect to intracellular signaling pathways and the actin cytoskeleton to regulate adhesion-dependent cellular processes. In cancer, the dynamic regulation of adhesion by integrins is critical for cell attachment to ECM, cell proliferation, invasion and cell migration. However, the intracellular downstream effectors of integrins that are important for oral cancer migration, invasion and metastasis are not well understood. Our aim is to compare the composition of integrin associated complexes derived from highly and poorly metastatic oral carcinoma cells. This proteomics study will identify candidate integrin downstream factors that either associate with distinct integrin receptors or specifically associate with integrins in a particular metastatic state. Future studies will delineate whether the identified factors regulate invasion and metastasis, as well as the molecular pathways involved in regulating these metastatic phenotypes.