INTEGRIN ASSOCIATED PROTEINS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 整合素受体与细胞外基质（ECM）配体结合，并选择性地连接到细胞内信号传导途径和肌动蛋白细胞骨架，以调节粘附依赖性细胞过程。在癌症中，整合素对粘附的动态调节对于细胞附着于ECM、细胞增殖、侵袭和细胞迁移是至关重要的。然而，对于口腔癌迁移、侵袭和转移重要的整合素的细胞内下游效应物尚不清楚。我们的目的是比较整合素相关复合物的组成，来自高转移性和低转移性口腔癌细胞。这项蛋白质组学研究将确定候选整合素下游因子，这些因子与不同的整合素受体相关或与特定转移状态下的整合素特异性相关。未来的研究将描述是否确定的因素调节侵袭和转移，以及参与调节这些转移表型的分子途径。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Integrin receptors bind to extracellular matrix (ECM) ligands and selectively connect to intracellular signaling pathways and the actin cytoskeleton to regulate adhesion-dependent cellular processes. In cancer, the dynamic regulation of adhesion by integrins is critical for cell attachment to ECM, cell proliferation, invasion and cell migration. However, the intracellular downstream effectors of integrins that are important for oral cancer migration, invasion and metastasis are not well understood. Our aim is to compare the composition of integrin associated complexes derived from highly and poorly metastatic oral carcinoma cells. This proteomics study will identify candidate integrin downstream factors that either associate with distinct integrin receptors or specifically associate with integrins in a particular metastatic state. Future studies will delineate whether the identified factors regulate invasion and metastasis, as well as the molecular pathways involved in regulating these metastatic phenotypes.