MRS DETECTS METABOLIC DYSFUNCTION AFTER BRAIN INJURY

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 入选UCLA脑损伤研究中心的创伤性脑损伤患者在入院时、ICU住院期间以及出院后长期随访期间接受多次脑MRI扫描。 迄今为止的证据表明，这些患者的局部和区域性白质和灰质萎缩随着时间的推移而增加。 我们将尝试使用LONI Pipeline V1分析全脑和半球选定区域（包括额叶、基底额叶、海马、顶叶和枕叶区域）的体积测量和皮质提取，我们还将逐个检查血肿和血肿周围区域的体积和体积变化。 将通过线性混合建模和相关性研究分析所得到的体积和皮质厚度，并测量在同一患者样本中获得的代谢、神经和心理状态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Traumatic brain injury patients enrolled into the UCLA Brain Injury Research Center receive multiple brain MRI scans at time of admission, during ICU stay, and again during long-term followup after hospital discharge. Evidence to date demonstrates significant localized and regional white-matter and grey-matter atrophy in increments over time in these patients. We will seek to analyze volumetrics and cortical extractions using the LONI Pipeline V1 in the whole brain and in selected regions by hemisphere, including frontal, basal frontal, hippocampal, parietal and occipital regions, and we will also examine volumes and volume changes in hematoma and perihematomal areas on a case-by-case basis. Resulting volumes and cortical thicknesses will be analyzed by linear mixed modeling and by correlation studies with measures of metabolism and neurological and psychological status obtained in the same patient sample.