DNA DESIGNER CRYSTALS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的研究计划旨在利用基于分支DNA的新型大分子构建模块，作为特定3D结构设计的基础。开发该系统的目标是最终提供一种大分子支架，能够结合，定向和并列各种分子，从细胞大分子到有机导体和光学存储组件。我们建议确定的三维周期阵列，这代表了第一个设计的三维系统的这种结构。这些系统很可能使以前难以处理的大分子物质的初始结晶，这种秩序，它也被设计为允许分析以前结晶的分子结合到配体的存在破坏了他们的传统晶格。在纳米尺度上产生特定结构的能力也应该使我们能够使用这个系统来产生连接到DNA单元的所谓货物杂分子的有序排列。例如，在3D中组织纳米电子组件，导致更小和可能更快的计算可能会从这项研究中产生

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our research program is designed to utilize new types of macromolecular building blocks, based on branched DNA, as the basis of specific 3D structural designs. The goal of developing the systems is eventually to provide a macromolecular scaffolding, capable of binding, orienting and juxtaposing a variety of molecules, from cellular macromolecules to organic conductors and optical memory components. We propose to determine the structures of 3D periodic arrays, which represent the first designed 3D systems of this sort. These systems are likely to enable the initial crystallization of macromolecular species previously intractable to such ordering, and it is also designed to allow analysis of previously crystallized molecules bound to ligands whose presence disrupts their conventional lattices. The ability to produce specific structures on the nanoscale should also enable us to use this system to produce ordered arrangements of so-called cargo hetero-molecules that are attached to the DNA units. For example, the organization of nanoelectronic components in 3D, leading to smaller and presumably faster computation could likely result from this research