DNA DESIGNER CRYSTALS

DNA 设计师水晶

• 批准号: 8170607
• 负责人: JENS J BIRKTOFT
• 金额: $ 1.78万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170607
• 关键词: Binding; Computer Retrieval of Information on Scientific Projects Database; Crystallization; DNA; Funding; Goals; Grant; Institution; Ligands; Memory; Optics; Research; Research Personnel; Resources; Sorting - Cell Movement; Source; Structure; System; United States National Institutes of Health; base; design; macromolecule; nanoelectronics; nanoscale; programs; prototype; scaffold; three dimensional structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our research program is designed to utilize new types of macromolecular building blocks, based on branched DNA, as the basis of specific 3D structural designs. The goal of developing the systems is eventually to provide a macromolecular scaffolding, capable of binding, orienting and juxtaposing a variety of molecules, from cellular macromolecules to organic conductors and optical memory components. We propose to determine the structures of 3D periodic arrays, which represent the first designed 3D systems of this sort. The ultimate goal here is to use these arrays to prototype a general form of macromolecular crystallization, in which the DNA components form the host lattice and all crystalline contacts, and macromolecular guests are aligned within the cavities present. This system is likely to enable the initial crystallization of macromolecular species previously intractable to such ordering, and it is also designed to allow analysis of previously crystallized molecules bound to ligands whose presence disrupts their conventional lattices. The ability to produce specific structures on the nanoscale should also enable us to use this system to produce ordered arrangements of so-called cargo hetero-molecules that are attached to the DNA units. Thus, the organization of nanoelectronic components in 3D, leading to smaller and presumably faster computation will likely result from this research

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的研究计划旨在利用基于分支DNA的新型大分子构建模块，作为特定3D结构设计的基础。开发该系统的目标是最终提供一种大分子支架，能够结合，定向和并列各种分子，从细胞大分子到有机导体和光学存储组件。我们建议确定的三维周期阵列，这代表了第一个设计的三维系统的这种结构。这里的最终目标是使用这些阵列来原型化大分子结晶的一般形式，其中DNA组分形成主体晶格和所有晶体接触，并且大分子客体在存在的空腔内对齐。该系统很可能使以前难以处理的大分子物种的初始结晶，这样的顺序，它也被设计为允许分析以前结晶的分子结合到配体的存在，破坏他们的传统晶格。在纳米尺度上产生特定结构的能力也应该使我们能够使用这个系统来产生连接到DNA单元的所谓货物杂分子的有序排列。因此，纳米电子组件在3D中的组织，导致更小和更快的计算可能会从这项研究中产生