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中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The research in my group is aimed at understanding molecular basis for biological activity and physical properties of integral membrane receptors, enzymes and ion channels involved in neurotransmission. To achieve our goals, three-dimensional structures are determined primarily by x-ray crystallography and functional properties of target proteins are assessed by structure-based site-directed mutagenesis in combination with biophysical and biochemical techniques including electrophysiology. Specifically, we are focusing on three classes of integral membrane proteins, which play key roles in mediating neuronal activities: NMDA receptors, a ligand-gated cation channel that opens upon binding to glutamate and glycine and mediate excitatory synaptic transmission; LDL receptor related protein (LRP), a lipoprotein receptor that associate with NMDA receptors and regulate the strength of synaptic transmission; and gamma-secretase, an intramembrane cleaving protease (iCLIPs) that mediate regulated intramembrane proteolysis (RIP) of amyloid precursor protein (APP) to regulate the production of amyloid beta, a pathogenic product for Alzheimer's disease.
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Structure and function of hetero-multimeric ligand-gated ion channels
  • 批准号:
    10357877
  • 项目类别:
  • 资助金额:
    $55.76万
  • 财政年份:
    2019
  • 负责人:
    Hiroyasu Furukawa
  • 依托单位:
Structure and function of hetero-multimeric ligand-gated ion channels
  • 批准号:
    9905566
  • 项目类别:
  • 资助金额:
    $58.29万
  • 财政年份:
    2019
  • 负责人:
    Hiroyasu Furukawa
  • 依托单位:
Structure and function of hetero-multimeric ligand-gated ion channels
  • 批准号:
    10593042
  • 项目类别:
  • 资助金额:
    $55.76万
  • 财政年份:
    2019
  • 负责人:
    Hiroyasu Furukawa
  • 依托单位:
Structure and Function of Hetero-multimeric Glutamate Receptors
  • 批准号:
    8631945
  • 项目类别:
  • 资助金额:
    $35.91万
  • 财政年份:
    2014
  • 负责人:
    Hiroyasu Furukawa
  • 依托单位:
国内基金
海外基金
新型F-18标记香豆素衍生物PET探针的研制及靶向Alzheimer's Disease 斑块显像研究
  • 批准号:
    81000622
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    20.0万元
  • 批准年份:
    2010
  • 负责人:
    梁胜
  • 依托单位:
阿尔茨海默病(Alzheimer's disease,AD)动物模型构建的分子机理研究
  • 批准号:
    31060293
  • 项目类别:
    地区科学基金项目
  • 资助金额:
    26.0万元
  • 批准年份:
    2010
  • 负责人:
    郭亚芬
  • 依托单位:
跨膜转运蛋白21(TMP21)对引起阿尔茨海默病(Alzheimer'S Disease)的γ分泌酶的作用研究