WHITE MATTER ARCHITECTURE FROM DIFFUSION MRI

扩散 MRI 的白质结构

• 批准号: 8169707
• 负责人: Carl-Fredrik Westin
• 金额: $ 27.82万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169707
• 关键词: Anatomy; Architecture; Brain; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Diffusion; Dimensions; Funding; Goals; Grant; Image; Institution; Knowledge; Magnetic Resonance Imaging; Neural Pathways; Research; Research Personnel; Resolution; Resources; Schizophrenia; Source; Techniques; Technology; United States National Institutes of Health; White Matter Disease; expectation; image processing; improved; relating to nervous system; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the White Matter Architecture core (WMA) is to pursue technological developments that improve current understanding of white matter anatomy in the brain. Given the small dimension of the neural pathways in relation to current imaging resolution, these technologies are vital to analyzing and visualizing the neural anatomy in normal and diseased states. The clinical objective is to analyze abnormalities in white matter architecture that underlie schizophrenia, by using techniques in diffusion tensor magnetic resonance imaging (DT-MRI) and post-process imaging. The expectation is that new knowledge acquired from these studies not only will benefit the understanding and treatment of schizophrenia, but also a broad range of other white matter diseases.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 White Matter Architecture核心（WMA）的目标是追求技术 提高当前对大脑白质解剖结构的理解的进展。 鉴于与当前成像相关的神经通路的尺寸较小 分辨率，这些技术对于分析和可视化神经解剖结构至关重要 在正常和患病状态下。临床目标是分析白色异常 通过使用扩散张量技术来研究精神分裂症背后的物质结构 磁共振成像（DT-MRI）和后处理成像。期望是 从这些研究中获得的新知识不仅有利于理解 和治疗精神分裂症，还可以治疗广泛的其他脑白质疾病。