WHITE MATTER ARCHITECTURE FROM DIFFUSION MRI

扩散 MRI 的白质结构

• 批准号: 8362589
• 负责人: Carl-Fredrik Westin
• 金额: $ 32.26万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362589
• 关键词: Anatomy; Architecture; Brain; Clinical; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Dimensions; Funding; Goals; Grant; Image; Knowledge; Magnetic Resonance Imaging; National Center for Research Resources; Neural Pathways; Principal Investigator; Research; Research Infrastructure; Resolution; Resources; Schizophrenia; Source; Techniques; Technology; United States National Institutes of Health; White Matter Disease; cost; expectation; image processing; improved; neuroimaging; relating to nervous system; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of the White Matter Architecture core (WMA) is to pursue technological developments that improve current understanding of white matter anatomy in the brain. Given the small dimension of the neural pathways in relation to current imaging resolution, these technologies are vital to analyzing and visualizing the neural anatomy in normal and diseased states. The clinical objective is to analyze abnormalities in white matter architecture that underlie schizophrenia, by using techniques in diffusion tensor magnetic resonance imaging (DT-MRI) and post-process imaging. The expectation is that new knowledge acquired from these studies not only will benefit the understanding and treatment of schizophrenia, but also a broad range of other white matter diseases.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 白色物质架构核心(WMA)的目标是追求技术 提高目前对大脑白质解剖学的理解的进展。 考虑到神经通路相对于电流成像的小尺寸 分辨率，这些技术对于分析和可视化神经解剖是至关重要的 在正常和患病状态下。临床目标是分析白色的异常。 精神分裂症背后的物质结构，通过使用扩散张量技术 磁共振成像(DT-MRI)和后处理成像。人们的期望是 从这些研究中获得的新知识不仅有助于理解 和治疗精神分裂症，也包括广泛的其他脑白质疾病。