MODELING THE MECHANOCHEMICAL REGULATION OF CELL PROTRUSION

细胞突出的机械化学调节建模

• 批准号: 8169572
• 负责人: Gaudenz Danuser
• 金额: $ 3.26万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169572
• 关键词: Actins; Cell model; Cells; Computer Retrieval of Information on Scientific Projects Database; Cytoskeleton; F-Actin; Funding; Grant; Institution; Kinetics; Mediating; Modeling; Property; Regulation; Research; Research Personnel; Resources; Source; Tropomyosin; United States National Institutes of Health; polymerization; virtual

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The actin cytoskeleton near the protruding cell edge consists of two kinetically, kinematically, molecularly, and materially distinct networks. Only one of the two, which we refer to as the lamellipodium, has the properties of an Arp2/3-controlled, dendritically branched and treadmilling network. The second network, referred to as the lamella, does contain Arp2/3 as well, but its polymerization is largely independent of Arp2/3 activity. We hypothesize that the assembly of F-actin in the lamella is mediated by formins and tropomyosin. The aim of this project is to implement a Virtual Cell (VC) model of F-actin network assembly at the leading edge to predict the differential kinetics of simultaneous Arp2/3- and formin-mediated lamellipodium and lamella formation.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 靠近突起细胞边缘的肌动蛋白细胞骨架由两个动力学、运动学、分子和物质上截然不同的网络组成。两者中只有一种具有Arp2/3控制的树枝状分支和踏板网络的性质。第二个网络称为片层，也含有Arp2/3，但它的聚合在很大程度上与Arp2/3的活性无关。我们假设F-肌动蛋白在板层中的组装是由福尔马林和原肌球蛋白介导的。本项目的目的是在前沿实现F-肌动蛋白网络组装的虚拟细胞(VC)模型，以预测Arp2/3和Forin同时介导的板层和板层形成的差异动力学。