RESOLUTION LIMITS FOR FLUORESCENCE TOMOGRAPHIC MOLECULAR IMAGING

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们提出的研究，以确定使用过采样测量的荧光扩散光学层析成像（F-DOT）的分辨率限制。它将利用两个NCRR国家资源的综合专业知识：使用最近在杜克中心体内显微镜（CIVM）建立的分子成像工作台进行数据采集，并使用匹兹堡超级计算中心（PSC）的并行计算设施进行图像重建。具体而言，我们将进行以下研究：（i）开发用于F-DOT模拟和图像重建的开放式结构软件包;（ii）在没有先验信息的情况下研究幻影和动物的分辨率极限;以及（iii）研究通过从micro-CT同时获取先验信息来改善分辨率极限。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are proposing studies to determine the resolution limits for fluorescence diffuse optical tomography (F-DOT) using over-sampled measurements. It will exploit the combined expertise of two NCRR National Resources: data acquisition using the recently established molecular imaging workbench at the Duke Center for In Vivo Microscopy (CIVM) and image reconstruction using the parallel computing facilities at the Pittsburgh Supercomputing Center (PSC). Specifically, we will be conducting the following studies: (i) Development of open-structured software package for F-DOT simulations and image reconstruction; (ii) Study of resolution limit in phantoms and animals without prior information; and (iii) Study the improvement of resolution limit with simultaneously acquired prior information from micro-CT.