RESOLUTION LIMITS FOR FLUORESCENCE TOMOGRAPHIC MOLECULAR IMAGING

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们提出的研究，以确定使用过采样测量的荧光扩散光学层析成像（F-DOT）的分辨率限制。它将利用两个NCRR国家资源的综合专业知识：使用最近在杜克中心体内显微镜（CIVM）建立的分子成像工作台进行数据采集，并使用匹兹堡超级计算中心（PSC）的并行计算设施进行图像重建。具体而言，我们将进行以下研究：（i）开发用于F-DOT模拟和图像重建的开放式结构软件包;（ii）在没有先验信息的情况下研究幻影和动物的分辨率极限;以及（iii）研究通过从micro-CT同时获取先验信息来改善分辨率极限。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are proposing studies to determine the resolution limits for fluorescence diffuse optical tomography (F-DOT) using over-sampled measurements. It will exploit the combined expertise of two NCRR National Resources: data acquisition using the recently established molecular imaging workbench at the Duke Center for In Vivo Microscopy (CIVM) and image reconstruction using the parallel computing facilities at the Pittsburgh Supercomputing Center (PSC). Specifically, we will be conducting the following studies: (i) Development of open-structured software package for F-DOT simulations and image reconstruction; (ii) Study of resolution limit in phantoms and animals without prior information; and (iii) Study the improvement of resolution limit with simultaneously acquired prior information from micro-CT.