Impaired mitochondrial energy metabolism and the therapeutic activity of Cu(atsm) in age and age-related neurodegenerative disease

线粒体能量代谢受损以及 Cu(atsm) 在年龄和年龄相关神经退行性疾病中的治疗活性

• 批准号: nhmrc : 1061550
• 负责人: A/Pr Paul Donnelly
• 金额: $ 46万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/impaired-mitochondrial-energy-neurodegenerative-disease/454907
• 关键词: Impaired; mitochondrial; energy; metabolism; therapeutic

Cognitive function and locomotor ability decline due to advanced age and disorders such as motor neuron disease, Alzheimer’s and Parkinson’s disease. We have identified a treatment that attenuates these symptoms of age and disease in mice, thus extending the healthy lifespan of the animals. This project will investigate the mechanisms by which the treatment works, thereby advancing our understanding of the causes of cognitive and locomotor decline and the development of preventative treatments.

认知功能和运动能力会因高龄以及运动神经元病、阿尔茨海默氏症和帕金森氏症等疾病而下降。我们已经确定了一种治疗方法，可以减轻小鼠的这些年龄和疾病症状，从而延长动物的健康寿命。这个项目将研究治疗的有效机制，从而促进我们对认知和运动能力下降的原因的理解，以及预防性治疗的发展。