3D IMAGING OF GAS EXCHANGE USING HYPERPOLARIZED 129XE MRI

使用超偏振 129XE MRI 对气体交换进行 3D 成像

• 批准号: 8171592
• 负责人: ZACKARY I CLEVELAND
• 金额: $ 1.64万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171592
• 关键词: Alveolar; Animal Model; Blood gas; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Development; Diffuse; Erythrocytes; Fibrosis; Funding; Gases; Grant; Health; Image; Institution; Lung; Lung diseases; Methods; Phase; Pulmonary Gas Exchange; Research; Research Personnel; Resources; Solubility; Source; Staging; Thick; Three-Dimensional Imaging; Time; Tissues; United States National Institutes of Health; Work; Xenon; base; in vivo; research study; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary aim is to develop a hyperpolarized (HP) 129Xe MRI-based method to study three dimensional pulmonary gas exchange in vivo. This method will exploit the large chemical shift range of 129Xe and the reasonably high solubility of xenon in tissues to differentially image the uptake of gas-phase, alveolar 129Xe by both the pulmonary blood/gas barrier tissue and red blood cells. Before reaching the red blood cells, HP 129Xe must first diffuse across the barrier tissue. Since diffusive transport times scale with the barrier thickness squared, 129Xe MR is capable of detecting barrier thickness changes as small as several microns. The initial stages of this work will focus on developing 3D gas exchange imaging capabilities. These efforts may involve constructing a gas exchange phantom that produces 129Xe NMR spectra that are similar to those observed in vivo before performing experiments with health controls. Following the development of 3D imaging capabilities, gas exchange in the healthy controls will be compared with well-known small animal models of pulmonary diseases involving gas exchange abnormalities such as fibrosis.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 主要目的是开发一种基于超极化（HP）129 MRI的方法来研究体内三维肺气体交换。 该方法将利用129氘的大化学位移范围和氙在组织中的合理的高溶解度来差分成像肺血液/气体屏障组织和红细胞两者对气相肺泡129氘的摄取。在到达红细胞之前，HP 129必须首先扩散穿过屏障组织。由于扩散传输时间与屏障厚度的平方成比例，因此129 μ mMR能够检测小至几微米的屏障厚度变化。这项工作的初始阶段将侧重于开发3D气体交换成像能力。这些努力可能涉及构建气体交换体模，其产生类似于在健康对照实验之前在体内观察到的129 NMR光谱。随着3D成像能力的发展，健康对照组的气体交换将与众所周知的涉及气体交换异常（如纤维化）的肺部疾病小动物模型进行比较。