IN VIVO 3D LUNG IMAGING WITH HYPERPOLARIZED 129XENON

使用超极化 129XENON 进行体内 3D 肺部成像

• 批准号: 8363180
• 负责人: ZACKARY I CLEVELAND
• 金额: $ 0.61万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363180
• 关键词: Breathing; Environmental air flow; Funding; Gases; Grant; Image; Lung; Magnetic Resonance Imaging; Methods; Microscopy; National Center for Research Resources; Phase; Principal Investigator; Rattus; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; in vivo; lung imaging; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of this study is to develop a robust method for 3D hyperpolarized (HP) 129Xe MR imaging of the rat lung. In this project, HP 129Xe will be delivered by inhalation, and both dissolved and gas-phase HP 129Xe will be imaged. Methods will be developed to co-register the dissolved and ventilation images and provide a novel method of detecting pathological changes in the lung.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的目的是开发一种稳定的方法，用于大鼠肺的3D超极化（HP）129 MR成像。在该项目中，HP 129 β将通过吸入方式输送，溶解和气相HP 129 β都将成像。将开发方法来共同配准溶解和通气图像，并提供一种新的方法来检测肺部的病理变化。