IN VIVO 3D LUNG IMAGING WITH HYPERPOLARIZED 129XENON

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究旨在建立一种稳健的大鼠肺三维超极化(HP)129Xe磁共振成像方法。在这个项目中，HP 129Xe将通过吸入的方式输送，并将对溶解的和气相的HP 129Xe进行成像。将开发一种方法来对溶解图像和通风图像进行联合配准，并提供一种检测肺部病变的新方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to develop a robust method for 3D hyperpolarized (HP) 129Xe MR imaging of the rat lung. In this project, HP 129Xe will be delivered by inhalation, and both dissolved and gas-phase HP 129Xe will be imaged. Methods will be developed to co-register the dissolved and ventilation images and provide a novel method of detecting pathological changed in the lung.