DETECTION OF MALARIA INFECTION IN ERYTHROCYTES BY RAMAN MICRO-SPECTROSCOPY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 疟疾仍然是世界上最大的公共卫生问题之一，每年造成近300万人死亡，主要是在撒哈拉以南非洲。在没有真正有效的疟疾疫苗的情况下，优先开展早期检测工作至关重要  特别是如果这种高度敏感的方法可以非侵入性地实施。近红外（NIR）拉曼光谱可能提供了一个很好的工具，探测疟疾在体内，鉴于其有前途的跟踪记录，经皮检测血液分析物，包括葡萄糖，肌酐和尿素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Malaria remains one of the largest public health problems accounting for nearly three million deaths a year in the world, primarily in sub-Saharan Africa. In the absence of a truly effective malarial vaccine, it is critical that early stage detection efforts are prioritized  especially if such a highly sensitive method can be implemented non-invasively. Near infrared (NIR) Raman spectroscopy potentially provides an excellent tool to probe malaria in vivo, given its promising track record in transcutaneous detection of blood analytes including glucose, creatinine and urea.