DETECTION OF MALARIA INFECTION IN ERYTHROCYTES BY RAMAN MICRO-SPECTROSCOPY

拉曼显微光谱法检测红细胞中的疟疾感染

• 批准号: 8364155
• 负责人: ISHAN BARMAN
• 金额: $ 2.97万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364155
• 关键词: Accounting; Africa South of the Sahara; Biomedical Research; Blood; Cessation of life; Creatinine; Detection; Erythrocytes; Funding; Glucose; Grant; Infection; Lasers; Malaria; Malaria Vaccines; Methods; National Center for Research Resources; Principal Investigator; Public Health; Raman Spectrum Analysis; Research; Research Infrastructure; Resources; Source; Spectrum Analysis; Staging; United States National Institutes of Health; Urea; cost; in vivo; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Malaria remains one of the largest public health problems accounting for nearly three million deaths a year in the world, primarily in sub-Saharan Africa. In the absence of a truly effective malarial vaccine, it is critical that early stage detection efforts are prioritized  especially if such a highly sensitive method can be implemented non-invasively. Near infrared (NIR) Raman spectroscopy potentially provides an excellent tool to probe malaria in vivo, given its promising track record in transcutaneous detection of blood analytes including glucose, creatinine and urea.

该子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 表示子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 疟疾仍然是世界上最大的公共卫生问题之一，每年造成近300万人死亡，主要是在撒哈拉以南非洲。在没有真正有效的疟疾疫苗的情况下，优先开展早期检测工作至关重要  特别是如果这种高度敏感的方法可以非侵入性地实施。近红外（NIR）拉曼光谱可能提供了一个很好的工具，探测疟疾在体内，鉴于其有前途的跟踪记录，经皮检测血液分析物，包括葡萄糖，肌酐和尿素。