EXPLORING THE ROLE OF CHOLESTEROL IN G-PROTEIN-COUPLED RECEPTOR FUNCTION, STABI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 要求MRAC拨款总额为1，344，000 SU时间（Ranger上1，152，000 SU和漫游中192，000 SU），用于在显式脂质膜环境中运行视紫红质、5-羟色胺（5-HT 2AR）和多巴胺（D2 R）G蛋白偶联受体（GPCR）的大规模分子动力学（MD）模拟。拟议的计算将支持实现计划项目赠款的具体目标（PPG：2 P01 DA 012923 -08，H。Weinstein，PI）。该项目的长期目标是研究特定胆固醇-受体相互作用在细胞信号传导过程中GPCR功能、稳定性和寡聚化中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A MRAC grant in the total amount of 1,344,000 SU time (1,152,000 SUs on Ranger and 192,000 SUs in roaming) is requested to run large-scale Molecular Dynamics (MD) simulations of Rhodopsin, Serotonin (5-HT2AR), and Dopamine (D2R) G-protein coupled receptors (GPCRs) in explicit lipid membrane environments. The proposed calculations will support achieving the specific aims of the Program Project Grant (PPG: 2 P01 DA012923-08, H. Weinstein, PI). The long-term goal of this project is to investigate the role of specific cholesterol-receptor interactions in GPCR functioning, stability, and oligomerization during cell signaling.