EXPLORING THE ROLE OF CHOLESTEROL IN G-PROTEIN-COUPLED RECEPTOR FUNCTION, STABI

探索胆固醇在 G 蛋白偶联受体功能 STABI 中的作用

• 批准号: 8364299
• 负责人: George Khelashvili
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364299
• 关键词: Biomedical Research; Cholesterol; DRD2 gene; Dopamine; Environment; Funding; G-Protein-Coupled Receptors; Goals; Grant; High Performance Computing; Membrane Lipids; National Center for Research Resources; Principal Investigator; Program Research Project Grants; Research; Research Infrastructure; Resources; Rhodopsin; Role; Running; Serotonin; Signal Transduction; Source; Time; United States National Institutes of Health; cost; molecular dynamics; receptor; receptor function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. A MRAC grant in the total amount of 1,344,000 SU time (1,152,000 SUs on Ranger and 192,000 SUs in roaming) is requested to run large-scale Molecular Dynamics (MD) simulations of Rhodopsin, Serotonin (5-HT2AR), and Dopamine (D2R) G-protein coupled receptors (GPCRs) in explicit lipid membrane environments. The proposed calculations will support achieving the specific aims of the Program Project Grant (PPG: 2 P01 DA012923-08, H. Weinstein, PI). The long-term goal of this project is to investigate the role of specific cholesterol-receptor interactions in GPCR functioning, stability, and oligomerization during cell signaling.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 请求 MRAC 拨款总计 1,344,000 SU 时间（Ranger 上的 1,152,000 SU 和漫游中的 192,000 SU），以便在明确的脂膜环境中对视紫红质、血清素 (5-HT2AR) 和多巴胺 (D2R) G 蛋白偶联受体 (GPCR) 进行大规模分子动力学 (MD) 模拟。拟议的计算将支持实现计划项目补助金的具体目标（PPG：2 P01 DA012923-08，H. Weinstein，PI）。该项目的长期目标是研究特定胆固醇受体相互作用在细胞信号传导过程中 GPCR 功能、稳定性和寡聚化中的作用。