HYPOGLYCEMIA AND HYPERGLYCEMIA IN DEVELOPING BRAIN

大脑发育中的低血糖和高血糖

• 批准号: 8170447
• 负责人: RADHAKRISHNA RAO
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170447
• 关键词: Acute; Animal Model; Brain; Computer Retrieval of Information on Scientific Projects Database; Functional disorder; Funding; Glucose; Grant; Hippocampus (Brain); Human; Hyperglycemia; Hypoglycemia; Institution; Metabolic; NMR Spectroscopy; Newborn Infant; Plasma; Process; Rattus; Recurrence; Research; Research Personnel; Resources; Source; United States National Institutes of Health; brain cell; neurochemistry; pup

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypoglycemia is a common metabolic condition in newborn infants. Prolonged and recurrent hypoglycemia is associated with long-term hippocampal dysfunction. Despite extensive studies in humans and animal models, detailed mechanism is not well understood, especially the sequel of different processes providing fuel for brain cells, when glucose plasma is too low. The purpose of this project is to quantify neurochemical changes during acute and recurrent hypoglycemia on the hippocampus of rat pups using 1H NMR spectroscopy at 9.4 T.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 低血糖症是新生儿常见的代谢疾病。长期和复发性低血糖与长期海马功能障碍有关。尽管在人类和动物模型中进行了广泛的研究，但详细的机制并没有得到很好的理解，特别是当血糖过低时，为脑细胞提供燃料的不同过程的后果。本研究的目的是利用9.4T核磁共振氢谱定量研究急性和反复低血糖时大鼠海马的神经化学变化。