HYPOGLYCEMIA AND HYPERGLYCEMIA IN DEVELOPING BRAIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 低血糖是新生儿常见的代谢性疾病。长期反复的低血糖与长期的海马体功能障碍有关。尽管在人类和动物模型中进行了广泛的研究，但详细的机制尚不清楚，特别是当血糖太低时，不同过程为脑细胞提供燃料的后遗症。本项目的目的是利用9.4T的~1H核磁共振波谱对急性和复发性低血糖时大鼠海马区的神经化学变化进行量化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypoglycemia is a common metabolic condition in newborn infants. Prolonged and recurrent hypoglycemia is associated with long-term hippocampal dysfunction. Despite extensive studies in humans and animal models, detailed mechanism is not well understood, especially the sequel of different processes providing fuel for brain cells, when glucose plasma is too low. The purpose of this project is to quantify neurochemical changes during acute and recurrent hypoglycemia on the hippocampus of rat pups using 1H NMR spectroscopy at 9.4 T.