HYPOGLYCEMIA AND HYPERGLYCEMIA IN DEVELOPING BRAIN

大脑发育中的低血糖和高血糖

• 批准号: 8362842
• 负责人: RADHAKRISHNA RAO
• 金额: $ 1.51万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362842
• 关键词: Acute; Animal Model; Brain; Functional disorder; Funding; Glucose; Grant; Hippocampus (Brain); Human; Hyperglycemia; Hypoglycemia; Magnetic Resonance Imaging; Metabolic; NMR Spectroscopy; National Center for Research Resources; Newborn Infant; Plasma; Principal Investigator; Process; Rattus; Recurrence; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; brain cell; cost; neurochemistry; pup

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Hypoglycemia is a common metabolic condition in newborn infants. Prolonged and recurrent hypoglycemia is associated with long-term hippocampal dysfunction. Despite extensive studies in humans and animal models, detailed mechanism is not well understood, especially the sequel of different processes providing fuel for brain cells, when glucose plasma is too low. The purpose of this project is to quantify neurochemical changes during acute and recurrent hypoglycemia on the hippocampus of rat pups using 1H NMR spectroscopy at 9.4 T.

这个子项目是利用这些资源的众多研究子项目之一