HUMORAL AND CELLULAR IMMUNE RESPONSES AGAINST SHIV INFECTION

针对 SHIV 感染的体液和细胞免疫反应

• 批准号: 8172683
• 负责人: Marie-Claire Elisabeth Gauduin
• 金额: $ 6.34万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172683
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adult; Animals; Antibody Formation; Biomedical Research; CD4 Positive T Lymphocytes; CD8B1 gene; Cells; Cessation of life; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Computer Simulation; Cytotoxic T-Lymphocytes; Development; Disease; Funding; Generations; Grant; HIV; HIV-1; Human; Immune; Immune response; Immunity; Infection; Institution; Laboratories; Learning; Monkeys; Organ; Patients; Persons; Pharmaceutical Preparations; Phase; Plasma; Production; Progressive Disease; Research; Research Institute; Research Personnel; Resources; SIV; Scientist; Source; T-Cell Depletion; T-Lymphocyte; Testing; Time; United States National Institutes of Health; Vaccines; Viral; Virus; Virus Diseases; Virus Replication; fighting; lymph nodes; neutralizing antibody; response; theories

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Acquired Immunodeficiency Syndrome (AIDS) is caused by a virus called the human immunodeficiency virus (HIV) and has resulted over the last 25 years in millions of death worldwide. The early phase of the infection is crucial in the eventual progress toward AIDS. Soon after entering the body, HIV rapidly spreads to the lymph nodes and others organs where it makes many millions of copies of itself. If the virus could be well contained at the beginning, the infected person would develop AIDS only after many years while a person with rapid expansion of the virus in the first days of infection would develop AIDS much sooner. Despite recent progress in our understanding of Human Immunodeficiency Virus disease the actual mechanisms responsible for controlling the replication of the virus in the infected host remain poorly understood. CD4+ T cell depletion and the progression of HIV-1-related diseases are progressive in adults infected with HlV-L Some of the reasons why adults are able to longer survive over the time of the infection may be due to differences in the host immune control of virus replication such as the stronger presence of CD8 cytotoxic T lymphocytes (or "killer T lymphocytes) and a better neutralizing antibody response, that have been shown to inhibit HIV replication. Animal studies can help address critical questions that cannot be answered in human studies, in computer models or laboratory dishes. Most animal AIDS research is conducted with monkeys. Some monkeys are infected with SIV, a virus very similar to HIV that causes an AIDS-like disease. The similarities between SIV and HIV allow scientists to test theories, vaccines, and medications that could otherwise never by tested. In collaboration with Dr. Leonidas Stamatatos from the Seattle Biomedical Research Institute (SBRI, Seattle WA), we will investigate the development of immunity to the virus longitudinally to determine how the body learns to fight SlV. We will particularly investigate the generation of virus-specific neutralizing antibodies and cellular immune responses such as the CD8 cytotoxic T lymphocyte responses in an effort to correlate these responses with control of virus concentration in the plasma. With this study, we are expecting to see an increased production of anti-virus neutralizing antibody responses and strong anti-viral cell responses that will mimic the immune responses observed during HIV infection in patient.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 获得的免疫缺陷综合征（AIDS）是由一种称为人类免疫缺陷病毒（HIV）的病毒引起的，在过去的25年中，全世界数百万死亡导致。感染的早期阶段对于最终朝着艾滋病的进展至关重要。进入身体后不久，艾滋病毒迅速传播到淋巴结和其他机器人，在那里它制作了数百万本身。如果一开始就可以很好地控制该病毒，那么感染者才会在多年后才发展艾滋病，而感染最初几天病毒迅速扩张的人会早日发展艾滋病。尽管我们对人类免疫缺陷病毒疾病的理解最近取得了进展，但负责控制感染宿主中该病毒复制的实际机制仍然很众所周知。 在感染HLV-L的成年人中，CD4+ T细胞的耗竭和与HIV-1相关疾病的进展是逐渐逐渐的抗体反应已显示可抑制HIV复制。 动物研究可以帮助解决人类研究，计算机模型或实验室菜肴中无法回答的关键问题。大多数动物艾滋病研究是通过猴子进行的。一些猴子感染了SIV，这种病毒与引起类似艾滋病疾病的HIV非常相似。 SIV和HIV之间的相似性使科学家可以测试否则可以通过测试的理论，疫苗和药物。 与西雅图生物医学研究所（SBRI，西雅图）的Leonidas Stamatatos博士合作，我们将纵向调查对病毒的免疫力的发展，以确定身体如何学会与SLV作战。我们将特别研究病毒特异性中和抗体和细胞免疫反应的产生，例如CD8细胞毒性T淋巴细胞反应，以努力将这些反应与血浆中病毒浓度的控制相关。通过这项研究，我们预计抗病毒中和抗体反应的产生和强烈的抗病毒细胞反应会增加，这些反应将模仿患者HIV感染期间观察到的免疫反应。