MOLECULAR AND CELLULAR TRANSPORT IN MUCUS

粘液中的分子和细胞运输

基本信息

  • 批准号:
    8172722
  • 负责人:
  • 金额:
    $ 4.8万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-05-01 至 2011-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently, more than 40 Million people worldwide are persistently infected with HIV-1. Similar to HIV infection in humans, SIV infection in Asian macaques results in chronic disease that culminates in AIDS. The well-defined SIV infection of rhesus macaques closely resembles many aspects of HIV infection in humans including events associated with transmission, cellular tropism of the virus, viral replication patterns, disease progression, and the nature of the host immune response. Furthermore, the SIV/macaque model is important because knowledge of the time, route, and number of viral exposures is known, the viral stock used to infect the macaques is well-characterized, and there is the ability to frequently sample important tissues (blood, lymph nodes, mucosal sites, etc) throughout infection. One of the current main lines of research in the field of AIDS is the identification of new treatments that will result in reduction or suppression of viral loads in infected individuals. The goal of this project is to determine the in vivo efficacy of biodegradable poly (lactic-co-glycolic acid) polymers (PLGA) nanoparticles that carry small interfering RNAs (siRNAs) specific for SIVmac. In order to target mainly infected cells, the particles will also be coated with anti-CD4 antibodies. This study will use rhesus macaques already infected with SIV. The animals proposed for the first year of the project are already available from other studies performed by our laboratory. For subsequent years we propose to use animals from other AIDS projects at SNPRC (such as vaccine projects) that become infected with SIV and are scheduled for euthanasia. Thus, we will not increase the use of na¿ve animals; rather, we will increase the scientific value of animals that otherwise would be scheduled for euthanasia. If the results of these studies are successful, these biodegradable nanoparticles could be used in humans as an addition to traditional antiviral therapy, or for the design of topical microbicides.
这个子项目是众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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W. Mark Saltzman其他文献

Next generation triplex-forming PNAs for site-specific genome editing of the F508del CFTR mutation
用于 F508del CFTR 突变位点特异性基因组编辑的下一代三链形成肽核酸
  • DOI:
    10.1016/j.jcf.2024.07.009
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
    6.000
  • 作者:
    Anisha Gupta;Christina Barone;Elias Quijano;Alexandra S. Piotrowski-Daspit;J. Dinithi Perera;Adele Riccardi;Haya Jamali;Audrey Turchick;Weixi Zao;W. Mark Saltzman;Peter M. Glazer;Marie E. Egan
  • 通讯作者:
    Marie E. Egan
Enhanced Intratumoral Delivery of Immunomodulator Monophosphoryl Lipid A through Hyperbranched Polyglycerol–Coated Biodegradable Nanoparticles
通过超支化聚甘油涂层的可生物降解纳米颗粒增强免疫调节剂单磷酰脂质 A 在肿瘤内的递送
  • DOI:
    10.1016/j.jid.2024.07.019
  • 发表时间:
    2025-03-01
  • 期刊:
  • 影响因子:
    5.700
  • 作者:
    Jungsoo Chang;Kwangsoo Shin;Julia M. Lewis;Hee Won Suh;Joohyung Lee;William Damsky;Suzanne Xu;Marcus Bosenberg;W. Mark Saltzman;Michael Girardi
  • 通讯作者:
    Michael Girardi
436 EFFECT OF SURVIVIN SIRNA AND VEGF SIRNA COMPLEXED IN NANOPARTICLES ON BLADDER CANCER CELLS AND UROTHELIAL TISSUES
  • DOI:
    10.1016/j.juro.2010.02.507
  • 发表时间:
    2010-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Alexander Saltzman;Kim Woodrow;Marcia A. Wheeler;Avanti Verma;W. Mark Saltzman;Robert M. Weiss
  • 通讯作者:
    Robert M. Weiss
1358 NANOPARTICLE DELIVERY OF THE HISTONE DEACETYLASE INHIBITOR PXD101 FACILITATES BLADDER CANCER CELL UPTAKE AND CYTOTOXICITY
  • DOI:
    10.1016/j.juro.2011.02.1180
  • 发表时间:
    2011-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Hristos Z. Kaimakliotis;Darryl T. Martin;Christopher J. Hoimes;Christopher C. Cheng;Jingchun Liu;Wm. Kevin Kelly;Gregory N. Tew;W. Mark Saltzman;Robert M. Weiss
  • 通讯作者:
    Robert M. Weiss
Cell-binding Peptides Conjugated to Poly(ethylene glycol) Promote Neural Cell Aggregation
与聚乙二醇结合的细胞结合肽促进神经细胞聚集
  • DOI:
    10.1038/nbt0894-797
  • 发表时间:
    1994-08-01
  • 期刊:
  • 影响因子:
    41.700
  • 作者:
    Weiguo Dai;Jennifer Belt;W. Mark Saltzman
  • 通讯作者:
    W. Mark Saltzman

W. Mark Saltzman的其他文献

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{{ truncateString('W. Mark Saltzman', 18)}}的其他基金

Engineering of Polymeric Particles for Fetal Therapy
用于胎儿治疗的聚合物颗粒工程
  • 批准号:
    10586282
  • 财政年份:
    2023
  • 资助金额:
    $ 4.8万
  • 项目类别:
Yale Interdisciplinary Bioengineering Training Grant for Diabetes Research
耶鲁大学糖尿病研究跨学科生物工程培训补助金
  • 批准号:
    8730154
  • 财政年份:
    2013
  • 资助金额:
    $ 4.8万
  • 项目类别:
Yale Interdisciplinary Bioengineering Training Grant for Diabetes Research
耶鲁大学糖尿病研究跨学科生物工程培训补助金
  • 批准号:
    8928174
  • 财政年份:
    2013
  • 资助金额:
    $ 4.8万
  • 项目类别:
Yale Interdisciplinary Bioengineering Training Grant for Diabetes Research
耶鲁大学糖尿病研究跨学科生物工程培训补助金
  • 批准号:
    8633896
  • 财政年份:
    2013
  • 资助金额:
    $ 4.8万
  • 项目类别:
MOLECULAR AND CELLULAR TRANSPORT IN MUCUS
粘液中的分子和细胞运输
  • 批准号:
    8357694
  • 财政年份:
    2011
  • 资助金额:
    $ 4.8万
  • 项目类别:
CED of Nanoparticles Loading with Novel Agents for Improved Treatment of Gliomas
载有新型药物的纳米颗粒的 CED 可改善神经胶质瘤的治疗
  • 批准号:
    8232044
  • 财政年份:
    2011
  • 资助金额:
    $ 4.8万
  • 项目类别:
CED of Nanoparticles Loading with Novel Agents for Improved Treatment of Gliomas
载有新型药物的纳米颗粒的 CED 可改善神经胶质瘤的治疗
  • 批准号:
    8107039
  • 财政年份:
    2011
  • 资助金额:
    $ 4.8万
  • 项目类别:
CED of Nanoparticles Loading with Novel Agents for Improved Treatment of Gliomas
载有新型药物的纳米颗粒的 CED 可改善神经胶质瘤的治疗
  • 批准号:
    8620614
  • 财政年份:
    2011
  • 资助金额:
    $ 4.8万
  • 项目类别:
CED of Nanoparticles Loading with Novel Agents for Improved Treatment of Gliomas
载有新型药物的纳米颗粒的 CED 可改善神经胶质瘤的治疗
  • 批准号:
    8444707
  • 财政年份:
    2011
  • 资助金额:
    $ 4.8万
  • 项目类别:
Optimizing Revascularization by EC Transplantation
通过 EC 移植优化血运重建
  • 批准号:
    7633385
  • 财政年份:
    2006
  • 资助金额:
    $ 4.8万
  • 项目类别:

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动物对陆地的最早探索:从痕迹化石到数值分析
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