POLYMORPHISM IN MACAQUE ANTI-RETROVIRAL FACTOR TRIM5ALPHA
POLYMORPHISM IN MACAQUE ANTI-RETROVIRAL FACTOR TRIM5ALPHA
批准号:
8172849
负责人:
Welkin E Johnson
金额:
$20.24万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-05-01 至 2011-04-30
关键词:
Anti-Retroviral AgentsComputer Retrieval of Information on Scientific Projects DatabaseFundingGenetic PolymorphismGenetic Population StudyGrantHIV-1InfectionInstitutionKnowledgeMacacaMediatingModelingOutcomePathogenesisPrimatesProteinsResearchResearch PersonnelResourcesSIVSourceUnited States National Institutes of Health
中文摘要
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。列出的机构是
研究中心,而研究中心不一定是研究者所在的机构。
灵长类TRIM 5 α蛋白介导一种有效的进入后阻断逆转录病毒感染。 我们正在研究灵长类动物TRIM 5 α的群体遗传学,并利用这些知识开发更好的HIV-1复制和发病机制模型,并确定TRIM 5 α多态性对SIV感染期间不同结果的影响。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The primate TRIM5alpha protein mediates a potent, post-entry block to retroviral infection. We are studying the population-genetics of primate TRIM5alpha and using this knowledge to develop better models for HIV-1 replication and pathogenesis, and in ascertaining the effects of TRIM5alpha polymorphism on differential outcome during SIV infection.
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POLYMORPHISM IN MACAQUE ANTI-RETROVIRAL FACTOR TRIM5ALPHA
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批准号:8357939
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项目类别:
-
资助金额:$20.46万
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财政年份:2011
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负责人:Welkin E Johnson
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依托单位:
Intrinsic Immunity and AIDS
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批准号:8690754
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项目类别:
-
资助金额:$67.06万
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财政年份:2011
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负责人:Welkin E Johnson
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依托单位:
Intrinsic Immunity and AIDS
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批准号:8493987
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项目类别:
-
资助金额:$52.63万
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财政年份:2011
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负责人:Welkin E Johnson
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依托单位:
Intrinsic Immunity and AIDS
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批准号:8472603
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项目类别:
-
资助金额:$58.0万
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财政年份:2011
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负责人:Welkin E Johnson
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依托单位:
Intrinsic Immunity and AIDS
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批准号:8210212
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项目类别:
-
资助金额:$17.31万
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财政年份:2011
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负责人:Welkin E Johnson
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依托单位:
Intrinsic Immunity and AIDS
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批准号:8299503
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项目类别:
-
资助金额:$55.99万
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财政年份:2011
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负责人:Welkin E Johnson
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依托单位:
Intrinsic Immunity and AIDS
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批准号:8867124
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项目类别:
-
资助金额:$48.49万
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财政年份:2011
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负责人:Welkin E Johnson
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依托单位:
STRATEGIES OF IMMUNE EVASION IN AIDS
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批准号:8357915
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项目类别:
-
资助金额:$21.06万
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财政年份:2011
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负责人:Welkin E Johnson
-
依托单位:
EDUCATION AND TRAINING
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批准号:8357897
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项目类别:
-
资助金额:$21.06万
-
财政年份:2011
-
负责人:Welkin E Johnson
-
依托单位:
STRATEGIES OF IMMUNE EVASION IN AIDS
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批准号:8172819
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项目类别:
-
资助金额:$20.24万
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财政年份:2010
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负责人:Welkin E Johnson
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依托单位:
EDUCATION AND TRAINING
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批准号:8172796
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项目类别:
-
资助金额:$24.11万
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财政年份:2010
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负责人:Welkin E Johnson
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依托单位:
Cross-Species transmission and adaptation of primate lentiviruses
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批准号:8494528
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项目类别:
-
资助金额:$36.05万
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财政年份:2009
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负责人:Welkin E Johnson
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依托单位:
Cross-Species transmission and adaptation of primate lentiviruses
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批准号:8291198
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项目类别:
-
资助金额:$38.35万
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财政年份:2009
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负责人:Welkin E Johnson
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依托单位:
Cross-species transmission and adaptation of primate lentiviruses
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批准号:8993274
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项目类别:
-
资助金额:$38.28万
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财政年份:2009
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负责人:Welkin E Johnson
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依托单位:
Cross-Species transmission and adaptation of primate lentiviruses
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批准号:8099685
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项目类别:
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资助金额:$37.79万
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财政年份:2009
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负责人:Welkin E Johnson
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依托单位:
EDUCATION AND TRAINING
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批准号:7958287
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项目类别:
-
资助金额:$23.79万
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财政年份:2009
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负责人:Welkin E Johnson
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依托单位:
Cross-Species transmission and adaptation of primate lentiviruses
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批准号:7896791
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项目类别:
-
资助金额:$42.94万
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财政年份:2009
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负责人:Welkin E Johnson
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依托单位:
Host Factor Genetics and Susceptibility to Retroviral Infection
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批准号:7916901
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项目类别:
-
资助金额:$43.38万
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财政年份:2009
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负责人:Welkin E Johnson
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依托单位:
Cross-Species transmission and adaptation of primate lentiviruses
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批准号:8472784
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项目类别:
-
资助金额:$4.73万
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财政年份:2009
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负责人:Welkin E Johnson
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依托单位:
POLYMORPHISM IN RHESUS MACAQUE ANTI-RETROVIRAL FACTOR TRIM5ALPHA
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批准号:7958356
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项目类别:
-
资助金额:$20.61万
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财政年份:2009
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负责人:Welkin E Johnson
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依托单位: