POLYMORPHISM IN MACAQUE ANTI-RETROVIRAL FACTOR TRIM5ALPHA

猕猴抗逆转录病毒因子 TRIM5ALPHA 的多态性

• 批准号: 8172849
• 负责人: Welkin E Johnson
• 金额: $ 20.24万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172849
• 关键词: Anti-Retroviral Agents; Computer Retrieval of Information on Scientific Projects Database; Funding; Genetic Polymorphism; Genetic Population Study; Grant; HIV-1; Infection; Institution; Knowledge; Macaca; Mediating; Modeling; Outcome; Pathogenesis; Primates; Proteins; Research; Research Personnel; Resources; SIV; Source; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primate TRIM5alpha protein mediates a potent, post-entry block to retroviral infection. We are studying the population-genetics of primate TRIM5alpha and using this knowledge to develop better models for HIV-1 replication and pathogenesis, and in ascertaining the effects of TRIM5alpha polymorphism on differential outcome during SIV infection.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 灵长类TRIM 5 α蛋白介导一种有效的进入后阻断逆转录病毒感染。 我们正在研究灵长类动物TRIM 5 α的群体遗传学，并利用这些知识开发更好的HIV-1复制和发病机制模型，并确定TRIM 5 α多态性对SIV感染期间不同结果的影响。