POLYMORPHISM IN MACAQUE ANTI-RETROVIRAL FACTOR TRIM5ALPHA

猕猴抗逆转录病毒因子 TRIM5ALPHA 的多态性

• 批准号: 8172849
• 负责人: Welkin E Johnson
• 金额: $ 20.24万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172849
• 关键词: Anti-Retroviral Agents; Computer Retrieval of Information on Scientific Projects Database; Funding; Genetic Polymorphism; Genetic Population Study; Grant; HIV-1; Infection; Institution; Knowledge; Macaca; Mediating; Modeling; Outcome; Pathogenesis; Primates; Proteins; Research; Research Personnel; Resources; SIV; Source; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primate TRIM5alpha protein mediates a potent, post-entry block to retroviral infection. We are studying the population-genetics of primate TRIM5alpha and using this knowledge to develop better models for HIV-1 replication and pathogenesis, and in ascertaining the effects of TRIM5alpha polymorphism on differential outcome during SIV infection.

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