POLYMORPHISM IN MACAQUE ANTI-RETROVIRAL FACTOR TRIM5ALPHA

猕猴抗逆转录病毒因子 TRIM5ALPHA 的多态性

• 批准号: 8357939
• 负责人: Welkin E Johnson
• 金额: $ 20.46万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357939
• 关键词: Anti-Retroviral Agents; Funding; Genetic Polymorphism; Genetic Population Study; Grant; HIV-1; Infection; Knowledge; Macaca; Mediating; Modeling; National Center for Research Resources; New England; Outcome; Pathogenesis; Primates; Principal Investigator; Proteins; Research; Research Infrastructure; Resources; SIV; Source; United States National Institutes of Health; base; cost

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The primate TRIM5alpha protein mediates a potent, post-entry block to retroviral infection. We are studying the population-genetics of primate TRIM5alpha and using this knowledge to develop better models for HIV-1 replication and pathogenesis, and in ascertaining the effects of TRIM5alpha polymorphism on differential outcome during SIV infection.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 灵长类动物 TRIM5alpha 蛋白介导对逆转录病毒感染的有效的进入后阻断。 我们正在研究灵长类 TRIM5alpha 的群体遗传学，并利用这些知识开发更好的 HIV-1 复制和发病机制模型，并确定 TRIM5alpha 多态性对 SIV 感染期间不同结果的影响。