MODIFIED HIV ENV IMMUNOGENS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 拟议的研究旨在定义候选HIV疫苗所引发的抗体的特定特征，这些抗体是保护免受感染所必需的。在本研究中，将测试三种不同的候选HIV疫苗。动物组将用三种疫苗之一免疫（三个免疫组和第四个作为未免疫对照组），然后暴露于SHIV。将在病毒暴露前后监测针对病毒的免疫应答。预期免疫动物将能够更好地控制病毒复制;事实上，与对照动物相比，一些动物可能完全免受感染。然而，在此阶段，我们不知道三种候选疫苗中的哪一种将引发更具保护性的抗病毒应答。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed study aims at defining specific features of antibodies elicited by candidate HIV vaccines that are required for protection from infection. In this study three different candidate HlV vaccines will be tested. The groups of animals will be immunized with one of the three vaccines (three immunization groups and a fourth that will serve as un-immunized control group) and then exposed to SHIV. The immune responses against the virus will be monitored before and following viral-exposure. It is anticipated that the immunized animals will be able to better control viral replication; in fact some animals may be completely protected from infection, than the control animals, A this stage however, we do not know which of the three candidate vaccines will elicit the more protective anti-viral responses.