MR SPECTROSCOPY IN THE SIV INFECTED MACAQUE MODEL OF NEUROAIDS
MR SPECTROSCOPY IN THE SIV INFECTED MACAQUE MODEL OF NEUROAIDS
批准号:
8172805
负责人:
RAMON GILBERTO GONZALEZ
金额:
$6.58万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-05-01 至 2011-04-30
关键词:
AIDS neuropathyAcquired Immunodeficiency SyndromeAnimalsAntibioticsBone MarrowCD8-Positive T-LymphocytesCerebrumComputer Retrieval of Information on Scientific Projects DatabaseDataDiseaseEventFundingGoalsGrantHIV InfectionsHighly Active Antiretroviral TherapyInjuryInstitutionLeadMacacaMacaca mulattaMagnetic ResonanceMeasurementMinocyclineModelingMonkeysNeurocognitiveNeuronal InjuryNeuronsPathogenesisPathway interactionsPatientsPhagocytesRecoveryResearchResearch PersonnelResourcesSIV encephalitisSourceSpectrum AnalysisTestingUnited States National Institutes of Healthantiretroviral therapymacrophagemonocytenervous system disordertheoriestrafficking
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Our goal is to elucidate the pathways that lead to cerebral injury by HIV infection. Without effective antiretroviral therapy (ART) treatment, approximately one third of AIDS patients will suffer from NeuroAIDS. A leading theory for the pathogenesis of neuroAIDS is that a specific bone marrow derived blood monocyte is virally infected and activated, then traffics into the CNS where it becomes a perivascular macrophage, setting off a cascade of events that result in neuronal injury. We seek to understand the dynamics of monocytic phagocyte (MP) trafficking, MP turnover in the CNS and neuronal recovery. Moreover, the persistence of cumulative neurological disease despite highly active antiretroviral therapy (HAART) has led to a search for adjunctive therapies. Recently, minocycline, a well-tolerated, inexpensive antibiotic has been tested on a variety of neuronal diseases, including NeuroAIDS. However, minocycline's mechanism of action towards HIV-associated neurocognitive disorders (HAND) remains unclear. The goal of our study is to unravel minocycline's mechanism(s) of action. Both goals will be accomplished by evaluating data collected from immunological, immunohistochemical, pathological, and magnetic resonance spectroscopic measurements of SIV-infected rhesus macaque monkeys. To this end we are utilizing the SIV-infected, CD8+ T lymphocyte-depleted macaque model (SIV+/CD8-) which typically results in a reliable accelerated model of neuroAIDS, as 95 percent of persistently (long-term) depleted animals demonstrate histopathological signs of SIV encephalitis.
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IN VIVO PROTON MRS REVEALS BRAIN REGION SPECIFIC METABOLIC RESPONSES TO SIV
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批准号:8358118
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项目类别:
-
资助金额:$5.78万
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财政年份:2011
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
MR SPECTROSCOPY IN THE SIV INFECTED MACAQUE MODEL OF NEUROAIDS
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批准号:8357903
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项目类别:
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资助金额:$6.84万
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财政年份:2011
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
IN VIVO PROTON MRS REVEALS BRAIN REGION SPECIFIC METABOLIC RESPONSES TO SIV
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批准号:8173030
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
MR SPECTROSCOPY IN THE SIV INFECTED MACAQUE MODEL OF NEUROAIDS
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批准号:7958297
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项目类别:
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资助金额:$11.19万
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财政年份:2009
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
MR SPECTROSCOPY IN THE SIV INFECTED MACAQUE MODEL
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批准号:7715427
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项目类别:
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资助金额:$23.79万
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财政年份:2008
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
MR SPECTROSCOPY OF BRAIN IN THE SIV INFECTED MACAQUE MODEL
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批准号:7562001
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项目类别:
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资助金额:$19.06万
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财政年份:2007
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
MR Spectroscopy of SIV Brain Injury
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批准号:7409646
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项目类别:
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资助金额:$67.47万
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财政年份:2005
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
MR Spectroscopy of SIV Brain Injury
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批准号:7047763
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项目类别:
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资助金额:$67.46万
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财政年份:2005
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
MR Spectroscopy of SIV Brain Injury
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批准号:6948415
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项目类别:
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资助金额:$72.7万
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财政年份:2005
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
MR Spectroscopy of SIV Brain Injury
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批准号:7210689
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项目类别:
-
资助金额:$67.47万
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财政年份:2005
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
MR Spectroscopy of SIV Brain Injury
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批准号:7587425
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项目类别:
-
资助金额:$69.5万
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财政年份:2005
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
MR SPECTROSCOPY OF BRAIN IN THE SIV INFECTED MACAQUE
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批准号:6971304
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项目类别:
-
资助金额:$10.87万
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财政年份:2004
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
MR SPECTROSCOPY STUDY OF SIV/MACAQUE NEUROAIDS
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批准号:6970789
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项目类别:
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资助金额:$4.72万
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财政年份:2004
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
ADVANCED MR SPECTROSCOPY OF BRAIN INJURY DUE TO SIV
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批准号:6940157
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项目类别:
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资助金额:$10.14万
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财政年份:2003
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
MOLECULAR NEUROIMAGING OF AIDS DEMENTIA: ANIMAL MODELS
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批准号:6355173
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项目类别:
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资助金额:$0.71万
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财政年份:2000
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
HIV ASSOCIATED NEUROTOXICITY & NMDA ANTAGONIST
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批准号:6355162
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项目类别:
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资助金额:$0.71万
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财政年份:2000
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
HIV ASSOCIATED NEUROTOXICITY & NMDA ANTAGONIST
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批准号:6118716
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项目类别:
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资助金额:$0.71万
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财政年份:1999
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
PREDICTING BRAIN TUMOR CHEMOSENSITIVITY BY IN VIVO MRS
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批准号:6514186
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项目类别:
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资助金额:$25.36万
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财政年份:1999
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
PREDICTING BRAIN TUMOR CHEMOSENSITIVITY BY IN VIVO MRS
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批准号:2908501
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项目类别:
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资助金额:$21.47万
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财政年份:1999
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
PREDICTING BRAIN TUMOR CHEMOSENSITIVITY BY IN VIVO MRS
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批准号:6173846
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项目类别:
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资助金额:$24.12万
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财政年份:1999
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负责人:RAMON GILBERTO GONZALEZ
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依托单位:
海外基金