IN VIVO PROTON MRS REVEALS BRAIN REGION SPECIFIC METABOLIC RESPONSES TO SIV

体内质子夫人揭示了大脑区域对 SIV 的特定代谢反应

• 批准号: 8358118
• 负责人: RAMON GILBERTO GONZALEZ
• 金额: $ 5.78万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358118
• 关键词: Basal Ganglia; Brain region; Choline; Creatine; Data; Funding; Glutamates; Glutamine; Grant; HIV; Human; Infection; Inositol; Macaca; Magnetic Resonance Spectroscopy; Metabolic; N-acetylaspartate; National Center for Research Resources; Neuronal Injury; Primates; Principal Investigator; Protons; Relative (related person); Research; Research Infrastructure; Resources; SIV; Source; Time; United States National Institutes of Health; Viremia; cost; falls; frontal lobe; in vivo; response; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background: In vivo proton magnetic resonance spectroscopy (1H-MRS) studies of HIV-infected humans have demonstrated significant metabolic abnormalities that vary by brain region, but the causes are poorly understood. Metabolic changes in the frontal cortex, basal ganglia and white matter in 18 SIV-infected macaques were investigated using MRS during the first month of infection. Results: Changes in the N-acetylaspartate (NAA), choline (Cho), myo-inositol (MI), creatine (Cr) and glutamine/glutamate (Glx) resonances were quantified both in absolute terms and relative to the creatine resonance. Most abnormalities were observed at the time of peak viremia, 2 weeks post infection (wpi). At that time point, significant decreases in NAA and NAA/Cr, reflecting neuronal injury, were observed only in the frontal cortex. Cr was significantly elevated only in the white matter. Changes in Cho and Cho/Cr were similar across the brain regions, increasing at 2 wpi, and falling below baseline levels at 4 wpi. MI and MI/Cr levels were increased across all brain regions. Conclusion: These data best support the hypothesis that different brain regions have variable intrinsic vulnerabilities to neuronal injury caused by the AIDS virus.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 背景：对HIV感染者的体内质子磁共振波谱(1H-MRS)研究表明，不同脑区存在明显的代谢异常，但其原因尚不清楚。用磁共振波谱技术研究了18只SIV感染猕猴额叶皮质、基底节和白质在感染后1个月内的代谢变化。 结果：N-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌醇(MI)、肌酸(Cr)和谷氨酰胺/谷氨酸(GLX)共振的变化在绝对值和相对肌酸共振值上都是定量的。大多数异常是在病毒血症高峰期，即感染后2周观察到的。此时，仅在额叶皮质观察到反映神经元损伤的NAA和NAA/Cr显著下降。肌酐仅在白质显著升高。各脑区Cho和Cho/Cr的变化相似，在2WPI时升高，4WPI时低于基线水平。MI和MI/Cr水平在所有脑区均升高。 结论：这些数据最好地支持了这样的假设，即不同的大脑区域对艾滋病病毒引起的神经元损伤具有不同的内在易感性。