MR SPECTROSCOPY OF BRAIN IN THE SIV INFECTED MACAQUE MODEL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的目标是阐明HIV感染导致脑损伤的途径。 感染后很快发生神经侵袭，30-40%的HIV感染者发展为AIDS痴呆综合征（ADC）。 神经AIDS发病机制的主要理论是特定的骨髓来源的血液单核细胞被病毒感染并活化，然后运输到CNS中，在那里它变成血管周围的巨噬细胞并引发导致神经元损伤的级联事件。 我们试图了解的动态单核吞噬细胞（MP）贩运，MP营业额在中枢神经系统和神经元的恢复，通过实验设计，测试一系列特定的假设来自中央理论。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to elucidate the pathways that lead to cerebral injury by HIV infection. Neuroinvasion occurs soon after infection and 30-40% of those infected with HIV develop AIDS dementia complex (ADC). A leading theory for the pathogenesis of neuroAIDS is that a specific bone marrow derived blood monocyte is virally infected and activated, then traffics into the CNS where it becomes a perivascular macrophage and sets off a cascade of events that result in neuronal injury. We seek to understand the dynamics of monocytic phagocytes (MP) trafficking, MP turnover in the CNS and neuronal recovery through an experimental design that tests a series of specific hypotheses derived from the central theory.