DEVELOPMENT OF A NON-HUMAN PRIMATE MODEL OF DIABETIC RETINOPATH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 糖尿病视网膜病变(DR)是劳动年龄人群失明的主要原因。不幸的是，没有可用的医学干预措施来预防或阻止糖尿病视网膜病变。DR的视网膜病变包括微动脉瘤、血管渗漏和出血、黄斑水肿和新生血管，这些都会导致严重的视力障碍。组织学损害，如基底膜(BM)增厚、周细胞丢失和无细胞毛细血管伴随临床损害，至少部分是由于高血糖。为了更好地了解DR的发病机制，人们在很大程度上依赖于并发症的动物模型，尽管主要是在大鼠模型中。灵长类DR模型的使用将在开发和评估新的治疗方法方面发挥独特的作用，因为它与人类以及相似的眼睛结构和功能具有密切的系统发育关系。常见的绒猴(Callithrix Jacchus)是一种新世界的猴子，已被用于寻找其他疾病的新疗法。绒猴的体重比成年老鼠轻，但眼睛几乎是老鼠眼睛的两倍。更重要的是，我们的初步数据表明，绒猴视网膜有一个中央黄斑，与人类视网膜相比，这是一个重要的解剖学相似之处，但在大鼠视网膜中没有。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diabetic retinopathy (DR) is the leading cause of blindness in the working age population. Unfortunately, no medical intervention is available to prevent or arrest diabetic retinopathy. The retinal lesions of DR include microaneurysms, vascular leakage and hemorrhage, macular edema and neovascularization, which lately will lead to great vision impairment. Histological lesions, such as basement membrane (BM) thickening, pericyte loss and acellular capillaries accompany the clinical lesions that develop, at least in part, due to hyperglycemia. The search for a better understanding of the pathogenesis of DR has relied heavily on animal models of the complications albeit mostly in the rat model. The use of primate models of DR would offer a distinct role in the development and assessment of novel treatments because of its close phylogenetic relationship with the human and similar eye structure and function. The common marmoset (Callithrix jacchus) is a new world monkey that has been used in the search for new treatments for other diseases. Marmosets weigh less than adult rats yet have eyes that are nearly twice the size of the rat eye. More importantly, our preliminary data indicates that the marmoset retina has a central macula, an important anatomical similarity compared to the human retina but absent in the rat retinas.