DEVELOPMENT OF A NON-HUMAN PRIMATE MODEL OF DIABETIC RETINOPATH

糖尿病视网膜病变非人灵长类动物模型的开发

• 批准号: 8172845
• 负责人: Sayon Roy
• 金额: $ 6.58万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172845
• 关键词: Adult; Age; Animal Model; Basement membrane; Blindness; Blood Vessels; Blood capillaries; Callithrix; Callithrix jacchus jacchus; Cebidae; Clinical; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diabetic Retinopathy; Disease; Extravasation; Eye; Funding; Grant; Hemorrhage; Human; Hyperglycemia; Impairment; Institution; Intervention; Lead; Lesion; Medical; Microaneurysm; Modeling; Pathogenesis; Pericytes; Phylogenetic Analysis; Population; Primates; Rattus; Research; Research Personnel; Resources; Retina; Retinal; Role; Source; Structure; United States National Institutes of Health; Vision; Work; capillary; diabetic; macula; macular edema; neovascularization; nonhuman primate; novel; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diabetic retinopathy (DR) is the leading cause of blindness in the working age population. Unfortunately, no medical intervention is available to prevent or arrest diabetic retinopathy. The retinal lesions of DR include microaneurysms, vascular leakage and hemorrhage, macular edema and neovascularization, which lately will lead to great vision impairment. Histological lesions, such as basement membrane (BM) thickening, pericyte loss and acellular capillaries accompany the clinical lesions that develop, at least in part, due to hyperglycemia. The search for a better understanding of the pathogenesis of DR has relied heavily on animal models of the complications albeit mostly in the rat model. The use of primate models of DR would offer a distinct role in the development and assessment of novel treatments because of its close phylogenetic relationship with the human and similar eye structure and function. The common marmoset (Callithrix jacchus) is a new world monkey that has been used in the search for new treatments for other diseases. Marmosets weigh less than adult rats yet have eyes that are nearly twice the size of the rat eye. More importantly, our preliminary data indicates that the marmoset retina has a central macula, an important anatomical similarity compared to the human retina but absent in the rat retinas.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 糖尿病视网膜病变（DR）是工作年龄人群失明的主要原因。不幸的是，没有医学干预可用于预防或阻止糖尿病视网膜病变。DR的视网膜病变包括微动脉瘤、血管渗漏和出血、黄斑水肿和新生血管，这些病变的出现将导致严重的视力损害。组织学病变，如基底膜（BM）增厚，周细胞损失和无细胞毛细血管伴随着临床病变的发展，至少部分是由于高血糖。为了更好地理解DR的发病机制，研究在很大程度上依赖于并发症的动物模型，尽管主要是在大鼠模型中。灵长类动物DR模型的使用将在开发和评估新的治疗方法中发挥独特的作用，因为它与人类有着密切的系统发育关系，并且具有相似的眼睛结构和功能。普通绒猴（Callithrix jacchus）是一种新的世界猴，已被用于寻找其他疾病的新疗法。绒猴的体重比成年大鼠轻，但眼睛的大小几乎是大鼠眼睛的两倍。更重要的是，我们的初步数据表明，绒猴视网膜有一个中央黄斑，一个重要的解剖相似性相比，人类视网膜，但缺乏在大鼠视网膜。