DEVELOPMENT OF A NON-HUMAN PRIMATE MODEL OF DIABETIC RETINOPATHY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 糖尿病视网膜病变(DR)是劳动年龄人群失明的主要原因。不幸的是，这种眼部并发症是无法治愈的。DR的视网膜病变包括微动脉瘤、血管渗漏、出血、黄斑水肿和新生血管，最终导致视力障碍或失明。组织学损害，如基底膜(BM)增厚、周细胞丢失和无细胞毛细血管伴随临床损害，至少部分是由于高血糖。为了更好地了解DR的发病机制，人们在很大程度上依赖于并发症的动物模型，尽管主要是在大鼠模型中。灵长类DR模型的使用将在开发和评估新的治疗方法方面发挥独特的作用，因为它与人类以及相似的眼睛结构和功能具有密切的系统发育关系。常见的绒猴(Callithrix Jacchus)是一种新世界的猴子，已被用于寻找其他疾病的新疗法。这些是小型灵长类动物，体重比成年老鼠轻，但眼睛几乎是老鼠眼睛的两倍。更重要的是，我们的初步数据表明，绒猴视网膜有一个中央黄斑，这是一个重要的解剖学特征，存在于人的视网膜中，但在大鼠的视网膜中缺失。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Diabetic retinopathy (DR) is the leading cause of blindness in the working age population. Unfortunately, there is no cure for this ocular complication. The retinal lesions of DR include microaneurysms, vascular leakage, hemorrhage, macular edema and neovascularization, which ultimately leads to vision impairment or blindness. Histological lesions, such as basement membrane (BM) thickening, pericyte loss and acellular capillaries accompany the clinical lesions that develop, at least in part, due to hyperglycemia. The search for a better understanding of the pathogenesis of DR has relied heavily on animal models of the complications albeit mostly in the rat model. The use of primate models of DR would offer a distinct role in the development and assessment of novel treatments because of its close phylogenetic relationship with the human and similar eye structure and function. The common marmoset (Callithrix jacchus) is a new world monkey that has been used in the search for new treatments for other diseases. These are small primates that weigh less than adult rats yet have eyes that are nearly twice the size of the rat eye. More importantly, our preliminary data indicates that the marmoset retina has a central macula, an important anatomical characteristic present in human retina but absent in the rat retina.