DEVELOPMENT OF A NON-HUMAN PRIMATE MODEL OF DIABETIC RETINOPATHY

糖尿病视网膜病变非人灵长类动物模型的开发

• 批准号: 8357936
• 负责人: Sayon Roy
• 金额: $ 5.4万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357936
• 关键词: Adult; Age; Animal Model; Basement membrane; Blindness; Blood Vessels; Blood capillaries; Callithrix; Callithrix jacchus jacchus; Cebidae; Characteristics; Clinical; Complication; Data; Development; Diabetic Retinopathy; Disease; Extravasation; Eye; Funding; Grant; Hemorrhage; Human; Hyperglycemia; Impairment; Lesion; Microaneurysm; Modeling; National Center for Research Resources; New England; Pathogenesis; Pericytes; Phylogenetic Analysis; Population; Primates; Principal Investigator; Rattus; Research; Research Infrastructure; Resources; Retina; Retinal; Role; Source; Structure; United States National Institutes of Health; Vision; Work; base; capillary; cost; macula; macular edema; neovascularization; nonhuman primate; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Diabetic retinopathy (DR) is the leading cause of blindness in the working age population. Unfortunately, there is no cure for this ocular complication. The retinal lesions of DR include microaneurysms, vascular leakage, hemorrhage, macular edema and neovascularization, which ultimately leads to vision impairment or blindness. Histological lesions, such as basement membrane (BM) thickening, pericyte loss and acellular capillaries accompany the clinical lesions that develop, at least in part, due to hyperglycemia. The search for a better understanding of the pathogenesis of DR has relied heavily on animal models of the complications albeit mostly in the rat model. The use of primate models of DR would offer a distinct role in the development and assessment of novel treatments because of its close phylogenetic relationship with the human and similar eye structure and function. The common marmoset (Callithrix jacchus) is a new world monkey that has been used in the search for new treatments for other diseases. These are small primates that weigh less than adult rats yet have eyes that are nearly twice the size of the rat eye. More importantly, our preliminary data indicates that the marmoset retina has a central macula, an important anatomical characteristic present in human retina but absent in the rat retina.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 糖尿病视网膜病变（DR）是工作年龄人群失明的主要原因。不幸的是，没有治愈这种眼部并发症的方法。DR的视网膜病变包括微动脉瘤、血管渗漏、出血、黄斑水肿和新生血管，最终导致视力障碍或失明。组织学病变，如基底膜（BM）增厚，周细胞损失和无细胞毛细血管伴随着临床病变的发展，至少部分是由于高血糖。为了更好地理解DR的发病机制，研究在很大程度上依赖于并发症的动物模型，尽管主要是在大鼠模型中。灵长类动物DR模型的使用将在开发和评估新的治疗方法中发挥独特的作用，因为它与人类有着密切的系统发育关系，并且具有相似的眼睛结构和功能。普通绒猴（Callithrix jacchus）是一种新的世界猴，已被用于寻找其他疾病的新疗法。这些小型灵长类动物的体重低于成年大鼠，但眼睛的大小几乎是大鼠眼睛的两倍。更重要的是，我们的初步数据表明，绒猴视网膜有一个中央黄斑，这是一个重要的解剖特征，存在于人类视网膜中，但在大鼠视网膜中没有。