PHYSIOLOGY AND PATHOPHYSIOLOGY OF BASAL GANGLIA IN PARKINSON?S DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 目的：利用帕金森病恒河猴模型和脑深部电刺激（DBS），探讨基底神经节与运动和感觉皮层作为一个功能单位的作用。 发展和改进硬膜外运动皮层刺激治疗运动障碍的方法。 开发和推进基底神经节-丘脑-皮质系统和DBS效应的计算建模。 我们开发了新的技术和方法来进行数据采集和分析。 我们在恒河猴的基底节-丘脑-皮质系统进行了微电极记录。 本研究使用WNPRC Animal Services和WNPRC Operational Services（Shop）。 注：蒙哥马利博士在本报告所述期间转到亚拉巴马大学。他的相关出版物从他的威斯康星州的工作包括在这份报告中。 出版物： 单侧左丘脑底脑刺激缓解与帕金森病相关的获得性口吃步行者HC，菲利普斯DE，博斯韦尔DB，古特里BL，古特里SL，尼古拉斯AP，蒙哥马利EB，瓦茨RL。J Speech Lang Hear Res. 2009 Dec;52（6）：1652-7.PMID：19951930.

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To use rhesus monkey (Macaca mulatta) models of Parkinsonism and deep brain stimulation (DBS) as a way to probe how the basal ganglia and the motor and sensory cortex act as a functioning unit. To develop and advance the methods of Epidural Motor Cortex Stimulation for movement disorders. Develop and advance computational modeling of the basal ganglia-thalamic-cortical system and the effects of DBS. We developed new technologies and methodologies for data accusation and analysis. We conducted microelectrode recordings in the basal ganglia-thalamic-cortical system in rhesus monkeys. This research used WNPRC Animal Services and WNPRC Operational Services (Shop). Note: Dr. Montgomery transferred to the University of Alabama during this reporting period. His related publications from his Wisconsin work are included in this report. PUBLICATIONS: Relief of acquired stuttering associated with Parkinson's disease by unilateral left subthalamic brain stimulation. Walker HC, Phillips DE, Boswell DB, Guthrie BL, Guthrie SL, Nicholas AP, Montgomery EB, Watts RL. J Speech Lang Hear Res. 2009 Dec;52(6):1652-7.PMID: 19951930.