HEART DYSAUTONOMIA IN PARKINSON'S DISEASE

帕金森病的心脏自主神经功能障碍

• 批准号: 8173143
• 负责人: MARINA EMBORG
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173143
• 关键词: Affect; Arrhythmia; Autonomic Dysfunction; Biological Assay; Computer Retrieval of Information on Scientific Projects Database; Dysautonomias; Funding; Grant; Heart; Hypotension; Image; Institution; Modeling; Nerve Degeneration; Neurons; Neurotoxins; Organ; Oxidopamine; Parkinson Disease; Patients; Preparation; Publications; Research; Research Personnel; Resources; Services; Source; Symptoms; Testing; United States National Institutes of Health; intravenous administration; nerve supply; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To develop tests to access autonomic dysfunction induced by systemic administration of the neurotoxin 6 hydroxydopamine. PD is associated with loss of autonomic innervation. The heart is one key organ affected. As such, PD patients present heart dysautonomia symptoms like autostatic hypotension or arrhythmias. Currently, there are not well characterized nonhuman primate models of these problems. Through an interdisciplinary team consisting of PD experts, cardiologists and imaging experts, we are developing a battery of tests to access autonomic dysfunction induced by systemic administration of the neurotoxin 6 hydroxydopamine. Preliminary results from this project suggest that intravenous administration of 6-OHDA induces neurodegeneration of catecholaminergic neurons innervating the heart and can be used to model heart autonomic dysfunction in PD. This research uses WNPRC Assay Services and CPI. A publication is in preparation.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：开发测试以访问由全身性施用神经毒素6羟基多巴胺引起的自主功能障碍。 PD与自主神经神经的丧失有关。心脏是受影响的一个关键器官。因此，PD患者表现出心脏动作障碍症状，例如自动性低血压或心律不齐。当前，这些问题的非人类灵长类动物模型没有很好的特征。通过由PD专家，心脏病专家和成像专家组成的跨学科团队，我们正在开发一系列测试，以访问由全身性给药神经毒素6羟基多巴胺引起的自主功能障碍。 该项目的初步结果表明，静脉注射6-OHDA会诱导神经心脏的儿茶酚胺能神经元的神经退行性，可用于模拟PD心脏自主神经功能障碍。 该研究使用WNPRC测定服务和CPI。 正在准备出版物。