SECULAR TREND OF BODY WEIGHT INCREASE AND EARLY PUBERTY

体重增加和性早熟的长期趋势

• 批准号: 8173163
• 负责人: Ei Terasawa-Grilley
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173163
• 关键词: Age; Animals; Body Weight; Computer Retrieval of Information on Scientific Projects Database; Diet; Female; Funding; Grant; Growth; Human; Information Services; Institution; Left; Macaca mulatta; Menarche; Monkeys; Obesity; Puberty; Records; Research; Research Personnel; Resources; Services; Societies; Source; Time; United States National Institutes of Health; Weight Gain; early onset; feeding; male; programs; trend

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To investigate whether there is any secular trend in body weight increase and early timing of puberty in rhesus monkeys in our colony. During the course of the 30-year studies, the age of menarche in experimental animals had become gradually younger, yet the body weight at menarche was the same. Thus, we have hypothesized that there is a secular trend in body weight increase and early onset of puberty in our colony monkeys. Extensive analysis of the colony records indicates that the body weight growth curve gradually left-shifted during the past 30 years in both females and males. Moreover, the age of menarche in colony females also became significantly younger during this period. Analysis of feeding programs during this period further suggested that monkeys in our current colony were fed a higher calorie diet than those 30 years ago. This secular trend towards obesity and menarche at younger ages in the WNPRC colony monkeys is strikingly similar to the trend in human society. The mechanism of body weight impact on puberty remains to be investigated. This research used WNPRC Animal Services and Information Services.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：探讨本群体恒河猴体重增长和青春期提前是否存在长期趋势。 在30年的研究过程中，实验动物的月经初潮年龄逐渐变得更年轻，但初潮时的体重是相同的。因此，我们假设，在我们的群体猴子中，体重增加和青春期提前存在长期趋势。 对群体记录的广泛分析表明，在过去的30年里，雌性和雄性的体重增长曲线都逐渐左移。此外，在此期间，群居雌性动物的月经初潮年龄也明显变得更年轻。对这一时期的喂养计划的分析进一步表明，我们当前群体中的猴子得到的饮食卡路里比30年前更高。在WNPRC群体中，猴子肥胖和月经初潮的长期趋势与人类社会的趋势惊人地相似。体重对青春期的影响机制还有待研究。 这项研究使用了WNPRC动物服务和信息服务。