PHARMACOLOGICAL BLOCKAGE OF A SELECTIVE CANNABINOID-1 RECEPTOR
PHARMACOLOGICAL BLOCKAGE OF A SELECTIVE CANNABINOID-1 RECEPTOR
批准号:
8172728
负责人:
ELIZABETH PARKS
金额:
$9.7万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-05-01 至 2011-04-30
关键词:
Body Weight decreasedCannabinoidsComputer Retrieval of Information on Scientific Projects DatabaseDoseEatingEndocannabinoidsFatty AcidsFatty acid glycerol estersFundingGrantInfusion proceduresInstitutionLipoproteinsLiverMeasuresMetabolicMethodsPilot ProjectsProcessProductionProtocols documentationRelative (related person)ResearchResearch PersonnelResourcesSourceTestingTriglyceridesUnited States National Institutes of HealthWeight-Loss Drugsdesigninsulin sensitivitylipoprotein triglycerideliver biopsymetabolic abnormality assessmentnonalcoholic steatohepatitisreceptorrimonabantstable isotope
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This pilot study was designed to 1) evaluate the changes in insulin sensitivity that can occur with weight loss, 2) demonstrate our ability to perform stable isotope infusion protocols, and 3) measure the relative sources of fats (triglycerides) that are secreted in lipoproteins and stored in the liver in Nonalcoholic Steatohepatitis (NASH) and to determine what effects the weight loss drug Rimonabant (A selective cannabinoid-1 receptor) has on this process. Stable isotope methods and liver biopsy will be used to achieve these research objectives. Past studies of endocannabinoid antagonist (EA) treatment have shown beneficial metabolic effects beyond those expected from weight loss alone. In the present study, metabolic studies will be performed to test the hypotheses that treatment with the EA, Rimonabant, at a dose below that which would impact food intake, would increase fatty acid usage and reduce lipoprotein-triglyceride (TG) production.
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PHARMACOLOGICAL BLOCKAGE OF A SELECTIVE CANNABINOID-1 RECEPTOR
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批准号:8357697
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项目类别:
-
资助金额:$5.69万
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财政年份:2011
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负责人:ELIZABETH PARKS
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依托单位:
PHARMACOKINETICS OF RIMONABANT IN FEMALE BABOONS
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批准号:8172654
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项目类别:
-
资助金额:$16.52万
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财政年份:2010
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负责人:ELIZABETH PARKS
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依托单位:
PHARMACOLOGICAL BLOCKAGE OF SELECTIVE CANNABINOID-1 RECEPTOR
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批准号:7957902
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项目类别:
-
资助金额:$1.63万
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财政年份:2009
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负责人:ELIZABETH PARKS
-
依托单位:
PHARMACOLOGICAL BLOCKAGE OF SELECTIVE CANNABINOID-1 RECEPTOR
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批准号:7716087
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项目类别:
-
资助金额:$0.24万
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财政年份:2008
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负责人:ELIZABETH PARKS
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依托单位:
HEDONICS AND FAT INTAKE
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批准号:7606359
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项目类别:
-
资助金额:$0.88万
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财政年份:2007
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负责人:ELIZABETH PARKS
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依托单位:
PHARMACOLOGICAL BLOCKAGE OF SELECTIVE CANNABINOID-1 RECEPTOR
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批准号:7562466
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项目类别:
-
资助金额:$2.68万
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财政年份:2007
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负责人:ELIZABETH PARKS
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依托单位:
海外基金