Indiana University Bloomington (IUB) Center for Cannabis, Cannabinoids, and Addiction (C3A)

印第安纳大学伯明顿分校 (IUB) 大麻、大麻素和成瘾中心 (C3A)

• 批准号: 10713089
• 负责人: Kenneth Mackie
• 金额: $ 167.47万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10713089
• 关键词: Address; Affect; Age; Anatomy; Applications Grants; Behavioral; Biological; Biological Markers; Brain; Cannabinoids; Cannabis; Cell physiology; Chronic; Collaborations; Creativeness; Cultured Cells; Data; Data Storage and Retrieval; Dopamine; Drug Addiction; Drug abuse; Education; Endocannabinoids; Ensure; Fostering; Foundations; Functional Imaging; Funding; Goals; Grant; Home; Illinois; Image; Imaging Techniques; In Vitro; Indiana; Individual; Institution; Intake; Kentucky; Knowledge; Learning; Letters; Light; Lipids; Mass Spectrum Analysis; Measures; Mentors; Microscopy; Midwestern United States; Modality; Molecular; Mus; National Institute of Drug Abuse; Neuromodulator; Neurosciences; Ohio; Optics; Paper; Participant; Pathway interactions; Pattern; Pharmaceutical Preparations; Pilot Projects; Plasma; Population; Predictive Factor; Process; Productivity; Public Health; Publishing; Qualifying; Recording of previous events; Relapse; Research; Research Personnel; Resources; Running; STEM career; Sampling; Scanning; Scientist; Serotonin; Services; Signal Transduction; Slide; Specimen; Structure; Substance Use Disorder; Talents; Techniques; Technology; Thinking; Training; Underrepresented Populations; United States National Institutes of Health; Universities; West Virginia; Withdrawal; Work; addiction; awake; career; compulsion; data dissemination; equipment acquisition; experience; experimental study; high resolution imaging; imaging approach; imaging modality; in vivo; in vivo calcium imaging; innovation; interest; lipid mediator; microscopic imaging; multi-photon; multimodality; multiphoton imaging; multiphoton microscopy; nanoscale; non-drug; novel; novel strategies; operation; optical imaging; outreach; phytocannabinoid; preservation; prevent; programs; reconstruction; sensor; superresolution microscopy; tissue fixing; underserved minority; university student

Abstract We are proposing to establish the IU Bloomington Center for Cannabis, Cannabinoid, and Addiction (IUB-C3A) as a NIDA Core Center for Excellence to serve addiction researchers both in the central Midwest and across the nation. This Center will offer core services to further our understanding of fundamental brain processes leading to or following the use of addictive drugs, particularly cannabis. The IUB-C3A will consist of two service cores, a pilot project core, and an administrative core. The Administrative Core will provide a well- defined structure for efficient center management, for public outreach, for organizing the Center’s courses, as well as for preserving and making easily accessible the data generated by the Center’s scientists. The Bioactive Lipid Mediators Core (BLMC) will provide analytical service for detecting cannabinoids and other bioactive lipid mediators in biological samples and run a summer course directed towards underserved minority college students interested in STEM careers. The MultiScale Imaging Core (MSIC) will offer services and training across a range of light microscopic imaging modalities. The multiphoton resource of the MSIC will include training and access to longitudinal in vivo imaging of calcium and other sensors (e.g., neuromodulators such as endocannabinoids, dopamine, and serotonin) from very young ages as well as long-range pathway tracing in “cleared” brain specimens. The STORM/confocal resource of the MSIC will offer users the opportunity to perform correlative structure/function studies from the macro- to nanoscale level and will also offer courses on these techniques. Both cores will emphasize innovation and integration of their respective techniques, as outlined in the proposal. The Pilot Project Core will solicit pilot projects from C3A Affiliates and investigators outside of the drug abuse field and mentor them through the process of obtaining data and NIDA support for their research ideas. The PIs for the IUB-C3A have a long history of productive collaborations, including publishing more than sixty papers together and holding several MPI NIH grants. The IUB-C3A is conceptualized as a resource that will offer opportunities for other addiction investigators across the Central Midwest (Southern Illinois, Indiana, Kentucky, Ohio, and West Virginia), a region strongly affected by drug addiction, and across the nation. The IUB-C3A aims to increase diversity in addiction research through a combination of summer experiences and pilot project programs targeted to under-represented populations in neuroscience and addiction. A core goal of these programs is to bring talented individuals into the field of addiction research. We anticipate that they will apply creative directions, rigorous experimental approaches, and novel ways of thinking to a major public health problem. The strong support of Indiana University to this endeavor is evident by generous matching funds for both equipment purchases and our diversity programs. All of these factors predict that the IUB-C3A will become a regional and national resource for better understanding and developing treatments for addictive disorders and their consequences.

摘要 我们建议建立IU布卢明顿大麻，大麻和成瘾中心（IUB-C3 A） 作为NIDA卓越核心中心，为中西部和全国的成瘾研究人员提供服务。 归国该中心将提供核心服务，以促进我们对基本大脑过程的理解 导致或随后使用成瘾药物，特别是大麻。IUB-C3 A将由两个 服务核心、试点项目核心和行政核心。行政核心将提供一个良好的- 为有效的中心管理，公共宣传，组织中心的课程， 以及保存和方便访问该中心科学家生成的数据。的 生物活性脂质介体核心（BLMC）将提供检测大麻素和其他 生物样品中的生物活性脂质介质，并针对服务不足的少数民族开设夏季课程 对STEM职业感兴趣的大学生。多尺度成像核心（MSIC）将提供服务， 在一系列光学显微镜成像模式的培训。MSIC的多光子资源将 包括训练和获得钙和其它传感器的纵向体内成像（例如，神经递质 如内源性大麻素、多巴胺和5-羟色胺）以及长距离途径 在“干净”的大脑样本中进行追踪。MSIC的STORM/共聚焦资源将为用户提供 有机会进行相关的结构/功能研究，从宏观到纳米级，也将 提供有关这些技术的课程。这两个核心都将强调创新和整合各自的 技术，如提案中所述。试点项目核心将征求C3 A附属公司的试点项目， 药物滥用领域以外的调查人员，并通过获取数据和NIDA的过程指导他们 支持他们的研究思路。IUB-C3 A的PI有着悠久的富有成效的合作历史， 包括发表了60多篇论文，并获得了多项MPI NIH赠款。IUB-C3 A是 概念化为一种资源，将为中央其他成瘾调查人员提供机会 中西部（伊利诺斯州南部、印第安纳州、肯塔基州、俄亥俄州和西弗吉尼亚州），受毒品严重影响的地区 上瘾，全国各地。IUB-C3 A旨在通过以下方式增加成瘾研究的多样性： 结合夏季经验和试点项目方案，针对代表性不足的人口， 神经科学和成瘾这些计划的核心目标是将有才华的个人带入该领域， 成瘾研究我们预计，他们将应用创造性的方向，严格的实验方法， 和新颖的思维方式来解决重大的公共卫生问题。印第安纳州大学对此的大力支持 奋进是显而易见的，为设备采购和我们的多样性计划慷慨的匹配资金。所有 这些因素预测IUB-C3 A将成为更好地了解 并开发治疗成瘾性疾病及其后果的方法。