WISCONSIN NATIONAL PRIMATE RESEARCH CENTER SUPPORT
WISCONSIN NATIONAL PRIMATE RESEARCH CENTER SUPPORT
批准号:
8173147
负责人:
DONNA M PAULNOCK
金额:
$5.16万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-05-01 至 2011-04-30
关键词:
AIDS VaccinesAllelesAnimalsClinicalCommunitiesComputer Retrieval of Information on Scientific Projects DatabaseDatabasesExhibitsFundingFutureGeneticGenotypeGrantHIVHIV vaccineHLA-B27 AntigenHLA-B57HeterogeneityHousingHumanImmuneIndividualInfectionInstitutionMHC Class I GenesMacacaMacaca mulattaMonitorPlayPrimatesResearchResearch PersonnelResourcesRunningSIVSamplingServicesSourceStudy modelsTimeUnited States National Institutes of HealthVaccinationVaccine DesignVaccine ResearchViralVirusVirus ReplicationWisconsinWorkbasecohortnonhuman primateresearch studyvaccine development
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Objective: To understand the immunological and genetic basis of control of AIDS virus replication to help inform vaccine design.
As in HIV-infected humans, a limited number of macaques, called "elite controllers (ECs)," spontaneously and effectively control SIV replication. Recently investigators in the UW-Madison/WNPRC AIDS Vaccine Research Lab identified sixteen ECs in a cohort of 196 Indian rhesus macaques. Genotyping for MHC class I alleles revealed that fourteen of these sixteen ECs expressed either Mamu-B*17 or Mamu-B*08, which appear to be the macaque functional equivalents of, in humans, HLA-B57 and HLA-B27, respectively. However, the monitoring and sampling of these animals, which were typically identified in the course of experiments run by different investigators, has not been consistent. Moreover, due to financial constraints, animals often must be euthanized at the end of specific studies. We plan to establish a sample bank, database, and to house existing and future EC macaques at the WNPRC. Making these unique resources available to the community of investigators working on SIV would be an extremely valuable service to the field. One of the biggest obstacles for HIV vaccine development is the lack of a clear understanding of the immune correlates for protection. Therefore, attempts to understand the potential mechanisms underlying apparent clinical protection in certain rare individuals (both human and macaque) who naturally exhibit protection without vaccination are highly significant. Studying elite controllers (ECs) of HIV replication is complicated by the fact that additional variables come into play, such as viral heterogeneity and the inability to know the source and timing of the infection. In contrast, nonhuman primate model studies allow uniformity of the viral inoculum by employing a single molecularly cloned virus.
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DIRECTOR'S OFFICE
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批准号:8173063
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项目类别:
-
资助金额:$10.33万
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财政年份:2010
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负责人:DONNA M PAULNOCK
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依托单位:
Modulation of innate immunity by microbial factors
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批准号:6463236
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项目类别:
-
资助金额:$18.19万
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财政年份:2002
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负责人:DONNA M PAULNOCK
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依托单位:
MACROPHAGE ACTIVATION IN AFRICAN TRYPANOSOMIASIS
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批准号:6434265
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项目类别:
-
资助金额:$32.53万
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财政年份:2002
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负责人:DONNA M PAULNOCK
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依托单位:
MACROPHAGE ACTIVATION IN AFRICAN TRYPANOSOMIASIS
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批准号:6621422
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项目类别:
-
资助金额:$32.52万
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财政年份:2002
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负责人:DONNA M PAULNOCK
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依托单位:
MACROPHAGE ACTIVATION IN AFRICAN TRYPANOSOMIASIS
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批准号:6698013
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项目类别:
-
资助金额:$32.51万
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财政年份:2002
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负责人:DONNA M PAULNOCK
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依托单位:
MACROPHAGE ACTIVATION IN AFRICAN TRYPANOSOMIASIS
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批准号:6838220
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项目类别:
-
资助金额:$32.5万
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财政年份:2002
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负责人:DONNA M PAULNOCK
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依托单位:
Modulation of innate immunity by microbial factors
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批准号:6888539
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项目类别:
-
资助金额:$18.19万
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财政年份:2002
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负责人:DONNA M PAULNOCK
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依托单位:
Modulation of innate immunity by microbial factors
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批准号:7067148
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项目类别:
-
资助金额:$17.76万
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财政年份:2002
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负责人:DONNA M PAULNOCK
-
依托单位:
Modulation of innate immunity by microbial factors
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批准号:6623118
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项目类别:
-
资助金额:$18.19万
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财政年份:2002
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负责人:DONNA M PAULNOCK
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依托单位:
MACROPHAGE ACTIVATION IN AFRICAN TRYPANOSOMIASIS
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批准号:7013654
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项目类别:
-
资助金额:$31.74万
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财政年份:2002
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负责人:DONNA M PAULNOCK
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依托单位:
Modulation of innate immunity by microbial factors
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批准号:6746890
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项目类别:
-
资助金额:$18.19万
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财政年份:2002
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负责人:DONNA M PAULNOCK
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依托单位:
GENE REGULATION DURING MACROPHAGE ACTIVATION
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批准号:2099649
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项目类别:
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资助金额:$9.7万
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财政年份:1995
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负责人:DONNA M PAULNOCK
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依托单位:
GENE REGULATION DURING MACROPHAGE ACTIVATION
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批准号:2099650
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项目类别:
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资助金额:$10.08万
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财政年份:1995
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负责人:DONNA M PAULNOCK
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依托单位:
GENE REGULATION DURING MACROPHAGE ACTIVATION
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批准号:2443023
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项目类别:
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资助金额:$10.49万
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财政年份:1995
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负责人:DONNA M PAULNOCK
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依托单位:
MONOCLONAL ANTIBODY ANALYSIS OF MACROPHAGE ACTIVATION
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批准号:3131243
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项目类别:
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资助金额:$12.21万
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财政年份:1984
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负责人:DONNA M PAULNOCK
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依托单位:
MONOCLONAL ANTIBODY ANALYSIS OF MACROPHAGE ACTIVATION
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批准号:3131247
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项目类别:
-
资助金额:$11.28万
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财政年份:1984
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负责人:DONNA M PAULNOCK
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依托单位:
MONOCLONAL ANTIBODY ANALYSIS OF MACROPHAGE ACTIVATION
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批准号:3131248
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项目类别:
-
资助金额:$10.85万
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财政年份:1984
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负责人:DONNA M PAULNOCK
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依托单位:
MONOCLONAL ANTIBODY ANALYSIS OF MACROPHAGE ACTIVATION
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批准号:3131245
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项目类别:
-
资助金额:$7.33万
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财政年份:1984
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负责人:DONNA M PAULNOCK
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依托单位:
MONOCLONAL ANTIBODY ANALYSIS OF MACROPHAGE ACTIVATION
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批准号:3131246
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项目类别:
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资助金额:$6.73万
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财政年份:1984
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负责人:DONNA M PAULNOCK
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依托单位:
海外基金