ESTABLISH & MAINTAIN CHIMP BIOMEDICAL RES COLONY: GENOME

建立

• 批准号: 8173563
• 负责人: THOMAS J ROWELL
• 金额: $ 21.23万
• 依托单位: UNIVERSITY OF LOUISIANA AT LAFAYETTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-09-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173563
• 关键词: Accreditation; Acquired Immunodeficiency Syndrome; Animal Model; Behavioral Research; Biological Availability; Breeding; Commit; Communities; Computer Retrieval of Information on Scientific Projects Database; Conceptions; Databases; Drug Compounding; Drug Kinetics; Evaluation; Family; Female; Funding; Gene Pool; Genetic; Genome; Grant; HIV; Hepatitis A Virus; Hepatitis B Vaccines; Hepatitis C virus; Housing; Institutes; Institution; International; Laboratory Animals; Long-Term Care; Measures; Methods; Modeling; Monoclonal Antibodies; Pan Genus; Partner in relationship; Pharmacodynamics; Play; Population; Proteins; Protocols documentation; Research; Research Personnel; Resources; Respiratory syncytial virus; Role; Safety; Source; System; Testing; United States National Institutes of Health; Work; abstracting; animal care; data sharing; demographics; male; meetings; novel; offspring; programs; vaccine development

DESCRIPTION (provided by applicant): The biomedical and behavioral research community has long recognized the importance of chimpanzees (Pan troglodytes) as an animal model. Several measures have been instituted to stabilize populations, which are threatened in the wild. Most notably, Nations of the Convention on International Trade in Endangered Species (CITES) have specifically prohibited the importation of chimpanzees from the wild for research purposes; and the National Institutes of Health (NIH) created the `Chimpanzee Breeding and Research Program (CBRP). In 1986, the CBRP was created to insure a chimpanzee population in the United States for use in human health research. The University of Louisiana at Lafayette has been active in this endeavor since its conception. Chimpanzees continue to be essential models in the development of vaccines for hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis A virus (HAV), respiratory syncytial virus (RSV), and human immunodeficiency virus (HIV). In addition they play a critical role in the evaluation of thepharmacodynamics, pharmacokinetics, bioavailablity, safety, and efficacy of novel drug compounds, proteins and monoclonal antibodies. Specific aims of the application include the following: * To maintain capabilities to successfully breed (once the breeding moratorium has been lifted) and house chimpanzees in UL Lafayette-NIRC's CBRP AAALAC International-accredited colony * To conduct a longitudinal study to examine neurochemical and neuroendocrine correlates of aggressive and affiliative/social behavior and determine how position in the dominance hierarchy is associated with these parameters. * To collaborate and share data freely with the chimpanzee database grantees, investigators whose efforts would be supported by access to UL Lafayette's information and the ChiMP Coordinator, and to work with the ChiMP Advisory, Panel in developing long term plans for research use, breeding colony size, demographics, genetics, and long-term care. * To support national and international efforts to share biomedical research resources consistent with the National Institutes of Health's policy on Sharing of Model Organisms for Biomedical Research, and to enhance the development of and access to chimpanzee animal models critical to understanding human health needs consistent with NCRR's 2004-2008 Strategic Plan.

描述（申请人提供）：生物医学和行为研究界长期以来一直认识到黑猩猩（Pan troglodytes）作为动物模型的重要性。已经制定了几项措施来稳定在野外受到威胁的种群。最值得注意的是，《濒危物种国际贸易公约》（CITES）的缔约国明确禁止为研究目的从野外进口黑猩猩;美国国立卫生研究院（NIH）设立了“黑猩猩繁殖和研究方案”（CBRP）。1986年，CBRP成立，以确保美国的黑猩猩种群用于人类健康研究。路易斯安那大学拉斐特分校自成立以来一直积极参与这一奋进。 黑猩猩仍然是开发B肝炎病毒（HBV）、丙型肝炎病毒（HCV）、甲型肝炎病毒（HAV）、呼吸道合胞病毒（RSV）和人类免疫缺陷病毒（HIV）疫苗的基本模型。此外，它们在评价新型药物化合物、蛋白质和单克隆抗体的药效学、药代动力学、生物利用度、安全性和有效性方面发挥关键作用。申请的具体目标包括： * 维持在UL Lafayette-NIRC的CBRP AAALAC国际认证的殖民地成功繁殖（一旦繁殖禁令解除）和圈养黑猩猩的能力 * 进行一项纵向研究，以检查攻击性和亲和/社交行为的神经化学和神经内分泌相关性，并确定统治等级中的地位如何与这些参数相关。 * 与黑猩猩数据库受资助者、研究人员（他们的工作将通过访问UL Lafayette的信息得到支持）和ChiMP协调员自由合作和共享数据，并与ChiMP咨询小组合作，制定研究使用、繁殖群体大小、人口统计学、遗传学和长期护理的长期计划。 * 支持国家和国际努力，以分享生物医学研究资源符合卫生部的政策，分享生物医学研究的模式生物，并加强黑猩猩动物模型的开发和访问至关重要的了解人类健康的需要符合NCRR的2004-2008年战略计划。