ESTABLISH & MAINTAIN CHIMP BIOMEDICAL RES COLONY: ANIMAL MODEL

描述（由申请人提供）：生物医学和行为研究界早已认识到黑猩猩（Pan troglodytes）作为动物模型的重要性。已经采取了多项措施来稳定野生动物受到威胁的种群数量。最值得注意的是，《濒危物种国际贸易公约》（CITES）成员国明确禁止出于研究目的进口野生黑猩猩；美国国立卫生研究院 (NIH) 创建了“黑猩猩育种和研究计划”(CBRP)。 1986 年，CBRP 成立，旨在确保美国黑猩猩种群用于人类健康研究。路易斯安那大学拉斐特分校自成立以来一直积极致力于这项工作。 黑猩猩仍然是乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）、甲型肝炎病毒（HAV）、呼吸道合胞病毒（RSV）和人类免疫缺陷病毒（HIV）疫苗开发的重要模型。此外，它们在评估新型药物化合物、蛋白质和单克隆抗体的药效学、药代动力学、生物利用度、安全性和功效方面发挥着关键作用。该应用程序的具体目标包括以下内容： * 保持在 UL Lafayette-NIRC 的 CBRP AAALAC 国际认证群体中成功繁殖（一旦取消繁殖暂停）和饲养黑猩猩的能力 * 进行纵向研究，检查攻击性和亲和/社会行为的神经化学和神经内分泌相关性，并确定支配等级中的位置如何与这些参数相关。 * 与黑猩猩数据库受赠者、研究人员（其工作将通过获取 UL Lafayette 的信息和 ChiMP 协调员来支持）自由合作和共享数据，并与 ChiMP Advisory 小组合作制定研究用途、繁殖群体规模、人口统计、遗传学和长期护理的长期计划。 * 支持国家和国际努力共享生物医学研究资源，符合美国国立卫生研究院关于共享生物医学研究模型生物的政策，并根据 NCRR 的 2004-2008 年战略计划，加强对了解人类健康需求至关重要的黑猩猩动物模型的开发和获取。

DESCRIPTION (provided by applicant): The biomedical and behavioral research community has long recognized the importance of chimpanzees (Pan troglodytes) as an animal model. Several measures have been instituted to stabilize populations, which are threatened in the wild. Most notably, Nations of the Convention on International Trade in Endangered Species (CITES) have specifically prohibited the importation of chimpanzees from the wild for research purposes; and the National Institutes of Health (NIH) created the `Chimpanzee Breeding and Research Program (CBRP). In 1986, the CBRP was created to insure a chimpanzee population in the United States for use in human health research. The University of Louisiana at Lafayette has been active in this endeavor since its conception. Chimpanzees continue to be essential models in the development of vaccines for hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis A virus (HAV), respiratory syncytial virus (RSV), and human immunodeficiency virus (HIV). In addition they play a critical role in the evaluation of thepharmacodynamics, pharmacokinetics, bioavailablity, safety, and efficacy of novel drug compounds, proteins and monoclonal antibodies. Specific aims of the application include the following: * To maintain capabilities to successfully breed (once the breeding moratorium has been lifted) and house chimpanzees in UL Lafayette-NIRC's CBRP AAALAC International-accredited colony * To conduct a longitudinal study to examine neurochemical and neuroendocrine correlates of aggressive and affiliative/social behavior and determine how position in the dominance hierarchy is associated with these parameters. * To collaborate and share data freely with the chimpanzee database grantees, investigators whose efforts would be supported by access to UL Lafayette's information and the ChiMP Coordinator, and to work with the ChiMP Advisory, Panel in developing long term plans for research use, breeding colony size, demographics, genetics, and long-term care. * To support national and international efforts to share biomedical research resources consistent with the National Institutes of Health's policy on Sharing of Model Organisms for Biomedical Research, and to enhance the development of and access to chimpanzee animal models critical to understanding human health needs consistent with NCRR's 2004-2008 Strategic Plan.