ESTABLISH & MAINTAIN CHIMP BIOMEDICAL RES COLONY: IMMUNOLOGY

描述(由申请人提供)：生物医学和行为研究界早就认识到黑猩猩(泛轮虫)作为动物模型的重要性。已经制定了几项措施来稳定在野外受到威胁的种群。最值得注意的是，《濒危物种国际贸易公约》(CITES)的成员国明确禁止出于研究目的从野外进口黑猩猩；美国国立卫生研究院(NIH)创建了“黑猩猩繁育和研究计划”(CBRP)。1986年，创建了CBRP，以确保美国的黑猩猩种群用于人类健康研究。路易斯安那大学拉斐特分校自成立以来一直积极参与这项工作。 黑猩猩仍然是研发乙肝病毒(乙肝)、丙型肝炎病毒(丙型肝炎)、甲型肝炎病毒(HAV)、呼吸道合胞病毒(RSV)和人类免疫缺陷病毒(HIV)疫苗的重要模型。此外，它们还在评价新型药物化合物、蛋白质和单抗的药效学、药代动力学、生物利用度、安全性和有效性方面发挥着关键作用。该应用程序的具体目标包括： *保持成功繁殖的能力(一旦繁殖禁令解除)，并在UL Lafayette-NIRC的CBRP AAALAC国际认可的殖民地饲养黑猩猩 *进行一项纵向研究，以检查神经化学和神经内分泌与攻击性和从属/社会行为的相关性，并确定在优势等级中的位置如何与这些参数相关。 *与黑猩猩数据库受赠者、研究人员合作并自由共享数据，他们的努力将得到UL Lafayette信息的访问和黑猩猩协调员的支持，并与黑猩猩咨询小组合作，为研究用途、繁殖群体规模、人口统计学、遗传学和长期护理制定长期计划。 *根据国家卫生研究院关于共享生物医学研究模式生物的政策，支持国家和国际努力共享生物医学研究资源，并根据NCRR的2004-2008年战略计划，加强对了解人类健康需求至关重要的黑猩猩动物模型的开发和获得。

DESCRIPTION (provided by applicant): The biomedical and behavioral research community has long recognized the importance of chimpanzees (Pan troglodytes) as an animal model. Several measures have been instituted to stabilize populations, which are threatened in the wild. Most notably, Nations of the Convention on International Trade in Endangered Species (CITES) have specifically prohibited the importation of chimpanzees from the wild for research purposes; and the National Institutes of Health (NIH) created the `Chimpanzee Breeding and Research Program (CBRP). In 1986, the CBRP was created to insure a chimpanzee population in the United States for use in human health research. The University of Louisiana at Lafayette has been active in this endeavor since its conception. Chimpanzees continue to be essential models in the development of vaccines for hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis A virus (HAV), respiratory syncytial virus (RSV), and human immunodeficiency virus (HIV). In addition they play a critical role in the evaluation of thepharmacodynamics, pharmacokinetics, bioavailablity, safety, and efficacy of novel drug compounds, proteins and monoclonal antibodies. Specific aims of the application include the following: * To maintain capabilities to successfully breed (once the breeding moratorium has been lifted) and house chimpanzees in UL Lafayette-NIRC's CBRP AAALAC International-accredited colony * To conduct a longitudinal study to examine neurochemical and neuroendocrine correlates of aggressive and affiliative/social behavior and determine how position in the dominance hierarchy is associated with these parameters. * To collaborate and share data freely with the chimpanzee database grantees, investigators whose efforts would be supported by access to UL Lafayette's information and the ChiMP Coordinator, and to work with the ChiMP Advisory, Panel in developing long term plans for research use, breeding colony size, demographics, genetics, and long-term care. * To support national and international efforts to share biomedical research resources consistent with the National Institutes of Health's policy on Sharing of Model Organisms for Biomedical Research, and to enhance the development of and access to chimpanzee animal models critical to understanding human health needs consistent with NCRR's 2004-2008 Strategic Plan.