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Establishment of Specific Pathogen-Free Rhesus Macaque Colonies

无特定病原体恒河猴群体的建立

基本信息

批准号：
7797977
负责人：
Cynthia J Doane
金额：
$ 32.24万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-30 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7797977
关键词：
Acquired Immunodeficiency Syndrome Address Adult Alleles Animal Experimentation Animal Model Animals Assisted Reproductive Technology Be++ element Beryllium Biomedical Research Bioterrorism Breeding CD8-Positive T-Lymphocytes Cells Chronic Country Disease Ensure Environment Epitopes Female Funding Future Genetic Genetic Materials Genetic Variation Grant HIV Histocompatibility Antigens Class II Housing Human Immune response Immune system Immunogenetics Inbreeding Infectious Agent Knowledge Macaca Macaca mulatta Major Histocompatibility Complex Measurement Mediating Methods Modeling Molecular Conformation Monitor National Center for Research Resources Oregon Other Genetics Pathogenesis Peptides Primate Lentiviruses Primates Production Recruitment Activity Request for Applications Research Research Infrastructure Research Personnel Resort Resources SIV Shelter facility Solutions Source Specific Pathogen Frees Surface T-Lymphocyte Target Populations Testing United States Public Health Service Vaccine Design Vaccine Research Vaccines Viral Virus Virus Diseases Virus Replication base cell mediated immune response cytotoxic design genetic pedigree germ free condition improved interest male microbial nonhuman primate offspring pandemic disease pre-clinical programs response simian human immunodeficiency virus tool vaccine development vaccine evaluation

项目摘要

DESCRIPTION (provided by applicant): The projected need for Indian rhesus macaques for AIDS-related research continues to exceed availability. Given the interest in nonhuman primates for bioterrorism and emerging disease research, this shortage will likely continue for years to come. While source countries are a potentially important reserve of untapped production the increasing difficulty of transporting nonhuman primate both internationally and domestically suggests relying on imports may provide only short term relief. Expanded domestic breeding programs managed to produce well characterized animals that enhance their use in biomedical research offer the best long-term solution for the current shortage of Indian-origin rhesus macaques for AIDS vaccine and pathogenesis studies and to insure future availability. The objective of this application is to continue expanding the capacity and improving on the level of genetic characterization of the specific pathogen-free Indian rhesus AIDS Research Colony resource initiated during the first grant period. The specific aim for accomplishing this objective is to intensively managing the new AIDS Research colony for maximum production of genetically diverse females to expand the breeding capacity. Selective breeding methods will be used to enhance production of future breeder males that are homozygous for scientifically important alleles. These animals can be used to efficiently produce large numbers of offspring carrying the desired allele without resorting to inbreeding The current level of genetic characterization in the colony will be expanded to include MHC class II loci. The acquisition of additional sheltered field cage housing is proposed to support colony expansion in an environment that protects these valuable animals from infectious agents in the environment.

描述（由申请人提供）：