Pursuing Perfection in Pediatric Theraputics

追求儿科治疗的完美

• 批准号: 8265042
• 负责人: Carole Marie Lannon
• 金额: $ 85万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8265042
• 关键词: Pursuing; Perfection; Pediatric; Theraputics

DESCRIPTION (provided by applicant): We aim to establish a pediatric Center for Education and Research on Therapeutics (CERTs) Research Center (RC) with the theme of improving care and outcomes for children by optimizing the use of therapeutics. Subthemes are quality and safety. With a core infrastructure at Cincinnati Children's Hospital Medical Center (CCHMC) and regional and national partnerships to enhance spread and translation into practice and policy, significant innovations in patient safety, comparative effectiveness and improvements in care can be achieved. Five projects are planned: 1) Reduce unsafe ICU transfers and the need for therapeutic interventions by using situation awareness, a high reliability strategy; 2) Predict and prevent acute kidney injury in hospitalized children receiving nephrotoxic medications by testing, refining, and spreading a trigger tool and mitigation intervention; 3) Compare the effectiveness of antibiotics for the most common serious bacterial infection in children, community acquired pneumonia, using a health system population database; 4) Evaluate diffusion and implementation strategies to prevent prematurity and related lung problems by using antenatal corticosteroids and 17-hydroxyprogesterone, in a statewide perinatal network; and 5) Ensure safe use of disease-modifying anti-rheumatic drugs, and develop a shared decision-making tool, in a pediatric network for the 6th most common cause of childhood disease, arthritis. We will use CCHMC and Learning Networks (multi-site collaborations of patients/families, clinicians, and researchers) as the innovation engines and laboratories that can help standardize care so that new approaches can be evaluated effectively and efficiently to improve therapeutic care and health outcomes for children. In addition, we propose activities that explore planned experimentation in complex health systems, and the ethics and data sharing policies needed to enable large registry studies. PUBLIC HEALTH RELEVANCE: Children have unique needs, types and severity of illness that create special challenges for pediatric therapeutics. Their care is suboptimal. This CERTs will focus on translating research into practice to improve quality and safety so that every child gets the right therapeutic at the right time in the right way--every time.

描述（由申请人提供）：我们的目标是建立一个儿科治疗学教育和研究中心 (CERT) 研究中心 (RC)，其主题是通过优化治疗的使用来改善儿童的护理和结果。次主题是质量和安全。凭借辛辛那提儿童医院医疗中心 (CCHMC) 的核心基础设施以及区域和国家合作伙伴关系来加强传播和转化为实践和政策，可以在患者安全、相对有效性和护理改善方面实现重大创新。计划实施五个项目：1）通过使用态势感知这一高可靠性策略，减少不安全的 ICU 转移和治疗干预的需要； 2）预测 通过测试、完善和传播触发工具和缓解干预措施，预防接受肾毒性药物的住院儿童发生急性肾损伤； 3) 使用卫生系统人口数据库，比较抗生素对儿童最常见的严重细菌感染——社区获得性肺炎的有效性； 4) 评估在全州围产期网络中使用产前皮质类固醇和 17-羟基孕酮来预防早产和相关肺部问题的推广和实施策略； 5) 确保安全使用缓解疾病的抗风湿药物，并在儿科网络中针对儿童疾病第六大常见原因关节炎开发共享决策工具。我们将利用 CCHMC 和学习网络（患者/家庭、临床医生和研究人员的多站点协作）作为创新引擎和实验室，帮助标准化护理，以便有效和高效地评估新方法，以改善儿童的治疗护理和健康结果。此外，我们还提出了探索复杂卫生系统中计划实验的活动，以及实现大型登记研究所需的伦理和数据共享政策。 公共卫生相关性：儿童有独特的需求、疾病类型和严重程度，这给儿科治疗带来了特殊的挑战。他们的护理不是最理想的。该 CERT 将专注于将研究转化为实践，以提高质量和安全性，以便每个孩子每次都能在正确的时间以正确的方式获得正确的治疗。