Administrative Core

摘要 我们的目标是在两种非人灵长类动物（NHP）移植模型中开发一种安全有效的、基于间充质干细胞（MSC）的共移植方案，最终可以在临床环境中进行测试，以改善胰岛和肾移植物的长期存活率和功能。我们将利用细胞（项目1）和实体器官（项目2）移植的食蟹猴模型，结合基因组学和蛋白质组学分析（核心B）、表型和功能测定（项目2）， 1和2），以及先进的数据分析工具（核心C）进行拟议的研究。行政核心的总体目标是协调项目和核心的活动，以确保一致性和积极的沟通，以及对数据的严格分析。Kenyon博士将担任联系PI和项目总监，并将与Laura Velez女士合作实现核心A的目标。目标1. 管理项目和核心的行政要求，包括预算、NIH报告、出版物处理和组织/协调Pls之间的月度电话会议和年度会议。目标二。跟踪从项目1（迈阿密，FL）和项目2（芝加哥，IL）到蛋白质组学和基因组学核心（核心B，拉霍亚，CA）的样本运输和接收。目标3：确保数据以可靠的方式传输到超级计算和多维数据分析核心（核心C）。目标4。 为了确保在获得结果后尽快在团队中讨论数据，以便通过早期识别任何技术或其他问题来最大限度地提高结果。作为核心A的项目总监和PI，Kenyon博士将负责协调整个项目，并确保就项目1和2中实验的共享方法保持良好的沟通， 真实的时间讨论实验结果，Core B收到的样品质量，以及Core C网站数据的频繁输入。

Abstract Our goal is to develop a safe and optimally effective, mesenchymal stem cell (MSC) based, cotransplant protocol in two nonhuman primate (NHP) transplantation models that can ultimately be tested in the clinical setting to improve long-term islet and renal allograft survival and function. We will utilize cynomolgus monkey models of cellular (Project 1) and solid organ (Project 2) transplantafion, in conjunction with genomics and proteomics analyses (Core B), phenotyping and functional assays (Projects 1 and 2), as well as sophisticated tools for data analysis (Core C) to undertake the proposed studies. The overall goal of the Administrative Core is to coordinate the activities of the Projects and Cores to ensure consistency and active communication, as well as rigorous analysis of the data. Dr. Kenyon will serve as contact PI and Program Director and will work with Ms. Laura Velez to achieve the Aims of Core A. Aim 1. To manage the administrative requirements of the Projects and Cores, including budgets, NIH reporting, publication processing and organization/coordination of monthly teleconferences and annual meefings among the Pls. Aim 2. To track shipping and receipt of samples from Projects 1 (Miami, FL) and 2 (Chicago, IL) to the Proteomics and Genomics Core (Core B, La Jolla, CA). Aim 3. To ensure transfer of data in a fimely manner to the Supercompufing and Multidimensional Data Analysis Core (Core C). Aim 4. To ensure that data is discussed among the team as soon as results become available, in order to maximize outcomes by identifying any technical or other problems eariy on. As Program Director and PI of Core A, it will be Dr. Kenyon's responsibility to coordinate the overall program and ensure that excellent communication is maintained regarding shared methods for conduct of the experiments in Projects 1 and 2, real fime discussion of experimental results, quality of samples received by Core B and frequent entry of data into the Core C website.