Task-free Presurgical Evaluation of Lateral, Eloquent Cortex & Epileptic Foci

描述(由申请人提供)：手术前评估受益于有关脑功能系统和功能失调组织的位置的信息。最近，基于功能核磁共振测量的自发活动分析的方法在识别受试者休息和睡眠时的大脑系统方面显示出了希望。在这里，我们将开发和评估一种新的方法，使用休息状态的内在活动来映射大脑中的多个系统，包括语言、记忆和运动系统。具体地说，该项目旨在解决手术前测绘中的三个关键挑战。首先，该项目将寻求开发一种新的语言和记忆侧化技术，作为替代传统侵入性WADA测试的候选技术。其次，我们假设皮层的基本区域可以使用与特定大脑系统相连的内在功能连接来绘制。最后，通过评估功能连接的中断，我们将寻求定位大脑病变和致痫皮质。该项目为脑损伤患者提出了一种新的术前标测方法，并有可能显著改进手术计划。 公共卫生相关性：这个项目旨在通过提供一种方法来取代传统的手术前标测，以最小的任务要求同时确定功能偏侧性、能言性皮质和癫痫灶。

DESCRIPTION (provided by applicant): Pre-surgical evaluation benefits from information about the location of functional brain systems and dysfunctional tissue. Recently, methods based on analysis of spontaneous activity measured by functional MRI have shown promise for identifying brain systems in subjects resting and while asleep. Here we will develop and evaluate a novel method using rest-state intrinsic activity to map multiple systems within the brain including language, memory, and motor systems. Specifically, this project aims to address three critical challenges in pre-surgical mapping. First, this project will seek to develop a new language and memory lateralization technique as a candidate to replace the traditional invasive Wada test. Second, we hypothesize that essential areas of cortex can be mapped using intrinsic functional connectivity linked to specific brain systems. Finally, by assessing the disruption of functional connectivity, we will seek to localize brain lesions and epileptogenic cortex. This project proposes a new approach for pre-surgical mapping for patients with brain lesions and has the potential to significantly improve surgical planning. PUBLIC HEALTH RELEVANCE: This project aims to replace the traditional pre-surgical mapping by providing a means to determine functional laterality, eloquent cortex and epileptic foci simultaneously and with minimal task requirements.