Task-free Presurgical Evaluation of Lateral, Eloquent Cortex & Epileptic Foci

描述（由申请人提供）：术前评估受益于有关功能性脑系统和功能障碍组织位置的信息。最近，基于功能性MRI测量的自发活动分析的方法已经显示出用于识别受试者休息和睡眠时的大脑系统的前景。在这里，我们将开发和评估一种新的方法，使用静息状态的内在活动映射大脑中的多个系统，包括语言，记忆和运动系统。具体而言，该项目旨在解决手术前映射的三个关键挑战。首先，该项目将寻求开发一种新的语言和记忆侧化技术，作为替代传统侵入性Wada测试的候选技术。第二，我们假设皮质的基本区域可以使用与特定大脑系统相关的内在功能连接来映射。最后，通过评估功能连接的中断，我们将寻求定位脑病变和致癫痫皮质。该项目提出了一种新的方法，用于脑病变患者的术前映射，并有可能显着改善手术计划。 公共卫生相关性：该项目旨在通过提供一种同时确定功能性偏侧性、功能性皮层和癫痫灶的方法，并以最小的任务要求取代传统的术前标测。

DESCRIPTION (provided by applicant): Pre-surgical evaluation benefits from information about the location of functional brain systems and dysfunctional tissue. Recently, methods based on analysis of spontaneous activity measured by functional MRI have shown promise for identifying brain systems in subjects resting and while asleep. Here we will develop and evaluate a novel method using rest-state intrinsic activity to map multiple systems within the brain including language, memory, and motor systems. Specifically, this project aims to address three critical challenges in pre-surgical mapping. First, this project will seek to develop a new language and memory lateralization technique as a candidate to replace the traditional invasive Wada test. Second, we hypothesize that essential areas of cortex can be mapped using intrinsic functional connectivity linked to specific brain systems. Finally, by assessing the disruption of functional connectivity, we will seek to localize brain lesions and epileptogenic cortex. This project proposes a new approach for pre-surgical mapping for patients with brain lesions and has the potential to significantly improve surgical planning. PUBLIC HEALTH RELEVANCE: This project aims to replace the traditional pre-surgical mapping by providing a means to determine functional laterality, eloquent cortex and epileptic foci simultaneously and with minimal task requirements.